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Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats
المؤلف
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Postprandial hyperglycemia is a predisposing factor for vascular dysfunction and organ damage.
α-glucosidase is a hydrolytic enzyme that increases the glucose absorption rate and subsequently elevates blood glucose levels.
Garlic (Allium sativum L.) is a rich source of several phytonutrients, including thiosulfinate (THIO).
The aim of this study was to evaluate the ability of THIO, a potent inhibitor of intestinal α-glucosidase, to reduce postprandial blood glucose.
Male albino rats were randomly assigned to five different groups ( n = 10 /group).
Group 1 served as the control group.
Groups 2–5 were injected intraperitoneally with a single dose of streptozotocin (STZ) to induce diabetes.
Group 2 comprised untreated diabetic rats.
Groups 3 and 4 contained diabetic rats that were given THIO orally (20 mg/kg body weight/day and 40 mg/kg body weight/day, resp.).
Group 5 was the positive control having diabetic rats treated orally with acarbose (10 mg/kg body weight/day; positive control).
Diabetic rats treated with THIO displayed a significant blood glucose reduction ( p < 0.001 and < 0.01 by analysis of variance, resp.) and a significant elevation in insulin compared with that of untreated rats.
THIO is an effective noncompetitive intestinal α-glucosidase inhibitor that promotes hypoglycemic action ( p < 0.001 ) in STZ-injected rats.
THIO is a promising agent for the management of postprandial hyperglycemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Malki, Abdulrahman L.. 2016. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Malki, Abdulrahman L.. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Malki, Abdulrahman L.. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104371
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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