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Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKACREB Signaling Pathway in Cerebral Hypoperfusion
المؤلفون المشاركون
Guo, Feng
Huang, Xiaolin
Zheng, Cai-Xia
Lu, Min
Guo, Ya-Bi
Zhang, Feng-Xia
Liu, Hua
Han, Xiaohua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Electroacupuncture (EA) has shown protective effects on cognitive decline.
However, the underlying molecular mechanisms are ill-understood.
The present study was undertaken to determine whether the cognitive function was ameliorated in cerebral hypoperfusion rats following EA and to investigate the role of PKA/CREB pathway.
We used a rat 2-vessel occlusion (2VO) model and delivered EA at Baihui (GV20) and Dazhui (GV14) acupoints.
Morris water maze (MWM) task, electrophysiological recording, Golgi silver stain, Nissl stain, Western blot, and real-time PCR were employed.
EA significantly (1) ameliorated the spatial learning and memory deficits, (2) alleviated long-term potentiation (LTP) impairment and the reduction of dendritic spine density, (3) suppressed the decline of phospho-CREB (pCREB) protein, brain-derived neurotrophic factor (BDNF) protein, and microRNA132 (miR132), and (4) reduced the increase of p250GAP protein of 2VO rats.
These changes were partially blocked by a selective protein kinase A (PKA) inhibitor, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinoline-sulfonamide (H89), suggesting that the PKA/CREB pathway is potentially involved in the effects of EA.
Moreover, any significant damage to the pyramidal cell layer of CA1 subregion was absent.
These results demonstrated that EA could ameliorate learning and memory deficits and alleviate hippocampal synaptic plasticity impairment of cerebral hypoperfusion rats, potentially mediated by PKA/CREB signaling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zheng, Cai-Xia& Lu, Min& Guo, Ya-Bi& Zhang, Feng-Xia& Liu, Hua& Guo, Feng…[et al.]. 2016. Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKACREB Signaling Pathway in Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zheng, Cai-Xia…[et al.]. Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKACREB Signaling Pathway in Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zheng, Cai-Xia& Lu, Min& Guo, Ya-Bi& Zhang, Feng-Xia& Liu, Hua& Guo, Feng…[et al.]. Electroacupuncture Ameliorates Learning and Memory and Improves Synaptic Plasticity via Activation of the PKACREB Signaling Pathway in Cerebral Hypoperfusion. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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