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Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro
المؤلفون المشاركون
Jeon, Yong-Deok
Park, Jinbong
Kim, Dae-Seung
Jeong, Mi-Young
Kim, Hye-Lin
Youn, Dong-Hyun
Kang, JongWook
Yoon, Daeyeon
Lee, Jong-Hyun
Hong, Seung-Heon
Um, Jae-Young
Lee, Junhee
Han, Yo-Han
Jung, Yunu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-06
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
This study was performed in order to investigate the antiobese effects of the ethanolic extract of Veratri Nigri Rhizoma et Radix (VN), a herb with limited usage, due to its toxicology.
An HPLC analysis identified jervine as a constituent of VN.
By an Oil Red O assay and a Real-Time RT-PCR assay, VN showed higher antiadipogenic effects than jervine.
In high-fat diet- (HFD-) induced obese C57BL/6J mice, VN administration suppressed body weight gain.
The levels of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT-enhancer-binding protein alpha (C/EBPα), adipocyte fatty-acid-binding protein (aP2), adiponectin, resistin, and LIPIN1 were suppressed by VN, while SIRT1 was upregulated.
Furthermore, VN activated phosphorylation of the liver kinase B1- (LKB1-) AMP-activated protein kinase alpha- (AMPKα-) acetyl CoA carboxylase (ACC) axis.
Further investigation of cotreatment of VN with the AMPK agonist AICAR or AMPK inhibitor Compound C showed that VN can activate the phosphorylation of AMPKα in compensation to the inhibition of Compound C.
In conclusion, VN shows antiobesity effects in HFD-induced obese C57BL/6J mice.
In 3T3-L1 adipocytes, VN has antiadipogenic features, which is due to activating the LKB1-AMPKα-ACC axis.
These results suggest that VN has a potential benefit in preventing obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Jinbong& Jeon, Yong-Deok& Kim, Hye-Lin& Kim, Dae-Seung& Han, Yo-Han& Jung, Yunu…[et al.]. 2016. Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104442
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Jinbong…[et al.]. Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104442
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Jinbong& Jeon, Yong-Deok& Kim, Hye-Lin& Kim, Dae-Seung& Han, Yo-Han& Jung, Yunu…[et al.]. Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104442
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104442
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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