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The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts
المؤلفون المشاركون
Xu, Tong
Wang, Lu
Tao, You
Ji, Yan
Deng, Feng
Wu, Xiao-Hong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Osteoporosis has become one of the most prevalent and costly diseases in the world.
It is a metabolic disease characterized by reduction in bone mass due to an imbalance between bone formation and resorption.
Osteoporosis causes fractures, prolongs bone healing, and impedes osseointegration of dental implants.
Its pathological features include osteopenia, degradation of bone tissue microstructure, and increase of bone fragility.
In traditional Chinese medicine, the herb Rhizoma Drynariae has been commonly used to treat osteoporosis and bone nonunion.
However, the precise underlying mechanism is as yet unclear.
Osteoprotegerin is a cytokine receptor shown to play an important role in osteoblast differentiation and bone formation.
Hence, activators and ligands of osteoprotegerin are promising drug targets and have been the focus of studies on the development of therapeutics against osteoporosis.
In the current study, we found that naringin could synergistically enhance the action of 1α,25-dihydroxyvitamin D3 in promoting the secretion of osteoprotegerin by osteoblasts in vitro.
In addition, naringin can also influence the generation of osteoclasts and subsequently bone loss during organ culture.
In conclusion, this study provides evidence that natural compounds such as naringin have the potential to be used as alternative medicines for the prevention and treatment of osteolysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Tong& Wang, Lu& Tao, You& Ji, Yan& Deng, Feng& Wu, Xiao-Hong. 2016. The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Tong…[et al.]. The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Tong& Wang, Lu& Tao, You& Ji, Yan& Deng, Feng& Wu, Xiao-Hong. The Function of Naringin in Inducing Secretion of Osteoprotegerin and Inhibiting Formation of Osteoclasts. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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