Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve
المؤلفون المشاركون
Alves, Péricles Barreto
Marchioro, M.
Medeiros Venancio, Antonio
Ferreira-da-Silva, Francisco Walber
da Silva-Alves, Kerly Shamyra
de Carvalho Pimentel, Hugo
Macêdo Lima, Matheus
Fraga de Santana, Michele
Batista da Silva, Givanildo
Leal-Cardoso, José Henrique
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The racemate linalool and its levogyrus enantiomer [(−)-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory.
In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L.
(EOOb) derived from Germplasm Bank rich in (−)-LIN content in the excitability of peripheral nervous system were studied.
We used rat sciatic nerve to investigate the EOOb and (−)-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP).
EOOb and (−)-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout.
EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38±0.2 and 0.17±0.0 mg/mL, respectively.
For (−)-LIN, these values were 0.23±0.0 and 0.13±0.0 mg/mL.
Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component.
In conclusion EOOb and (−)-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (−)-LIN in the essential oil.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Medeiros Venancio, Antonio& Ferreira-da-Silva, Francisco Walber& da Silva-Alves, Kerly Shamyra& de Carvalho Pimentel, Hugo& Macêdo Lima, Matheus& Fraga de Santana, Michele…[et al.]. 2016. Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Medeiros Venancio, Antonio…[et al.]. Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Medeiros Venancio, Antonio& Ferreira-da-Silva, Francisco Walber& da Silva-Alves, Kerly Shamyra& de Carvalho Pimentel, Hugo& Macêdo Lima, Matheus& Fraga de Santana, Michele…[et al.]. Essential Oil of Ocimum basilicum L. and (−)-Linalool Blocks the Excitability of Rat Sciatic Nerve. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر