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Transport of Corilagin, Gallic Acid, and Ellagic Acid from Fructus Phyllanthi Tannin Fraction in Caco-2 Cell Monolayers
المؤلفون المشاركون
Wang, Ru-Feng
Mao, Xin
Wu, Ling-Fang
Chen, Wen-Jing
Cui, Ya-Ping
Qi, Qi
Li, Shi
Liang, Wen-Yi
Yang, Guang-Hui
Shao, Yan-Yan
Zhu, Dan
You, Yun
Zhang, Lan-Zhen
Zhao, Hai-juan
Han, Shu-Xian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the absorption property of the representative hydrolyzable tannin, namely corilagin, and its hydrolysates gallic acid (GA) and ellagic acid (EA) from the Fructus Phyllanthi tannin fraction (PTF) in vitro.
Methods.
Caco-2 cells monolayer model was established.
Influences of PTF on Caco-2 cells viability were detected with MTT assay.
The transport across monolayers was examined for different time points, concentrations, and secretory directions.
The inhibitors of P-glycoprotein (P-gp), multidrug resistance proteins (MRPs), organic anion transporting polypeptide (OATP) and sodium/glucose cotransporter 1 (SGLT1), and tight junction modulators were used to study the transport mechanism.
LC-MS method was employed to quantify the absorption concentration.
Results.
The apparent permeability coefficient ( P a p p ) values of the three compounds were below 1.0 × 10−6 cm/s.
The absorption of corilagin and GA were much lower than their efflux, and the uptake of both compounds was increased in the presence of inhibitors of P-gp and MRPs.
The absorption of EA was decreased in the company of OATP and SGLT1 inhibitors.
Moreover, the transport of corilagin, GA, and EA was enhanced by tight junction modulators.
Conclusion.
These observations indicated that the three compounds in PTF were transported via passive diffusion combined with protein mediated transport.
P-gp and MRPs might get involved in the transport of corilagin and GA.
The absorption of EA could be attributed to OATP and SGLT1 protein.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mao, Xin& Wu, Ling-Fang& Zhao, Hai-juan& Liang, Wen-Yi& Chen, Wen-Jing& Han, Shu-Xian…[et al.]. 2016. Transport of Corilagin, Gallic Acid, and Ellagic Acid from Fructus Phyllanthi Tannin Fraction in Caco-2 Cell Monolayers. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104479
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mao, Xin…[et al.]. Transport of Corilagin, Gallic Acid, and Ellagic Acid from Fructus Phyllanthi Tannin Fraction in Caco-2 Cell Monolayers. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104479
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mao, Xin& Wu, Ling-Fang& Zhao, Hai-juan& Liang, Wen-Yi& Chen, Wen-Jing& Han, Shu-Xian…[et al.]. Transport of Corilagin, Gallic Acid, and Ellagic Acid from Fructus Phyllanthi Tannin Fraction in Caco-2 Cell Monolayers. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104479
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104479
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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