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Identification of a New Antibacterial Sulfur Compound from Raphanus sativus Seeds
المؤلفون المشاركون
Yazbak, Ahmad
Rushrush, Salwa
Rudy, Amira
Azaizeh, Hassan
Jadoun, Jeries
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-03
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Raphanus sativus L.
(radish), a member of Brassicaceae, is widely used in traditional medicine in various cultures for treatment of several diseases and disorders associated with microbial infections.
The antibacterial activity of the different plant parts has been mainly attributed to several isothiocyanate (ITC) compounds.
However, the low correlation between the ITC content and antibacterial activity suggests the involvement of other unknown compounds.
The objective of this study was to investigate the antibacterial potential of red radish seeds and identify the active compounds.
A crude ethanol seed extract was prepared and its antibacterial activity was tested against five medically important bacteria.
The ethanol extract significantly inhibited the growth of all tested strains.
However, the inhibitory effect was more pronounced against Streptococcus pyogenes and Escherichia coli.
Bioassay-guided fractionation of the ethanol extract followed by HPLC, 1H-NMR, 13C-NMR, 15N-NMR, and HMBC analysis revealed that the active fraction consisted of a single new compound identified as [5-methylsulfinyl-1-(4-methylsulfinyl-but-3-enyl)-pent-4-enylidene]-sulfamic acid, which consisted of two identical sulfur side chains similar to those found in ITCs.
The minimal inhibitory concentration values of the isolated compound were in the range of 0.5–1 mg/mL.
These results further highlight the role of radish as a rich source of antibacterial compounds.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jadoun, Jeries& Yazbak, Ahmad& Rushrush, Salwa& Rudy, Amira& Azaizeh, Hassan. 2016. Identification of a New Antibacterial Sulfur Compound from Raphanus sativus Seeds. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104487
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jadoun, Jeries…[et al.]. Identification of a New Antibacterial Sulfur Compound from Raphanus sativus Seeds. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104487
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jadoun, Jeries& Yazbak, Ahmad& Rushrush, Salwa& Rudy, Amira& Azaizeh, Hassan. Identification of a New Antibacterial Sulfur Compound from Raphanus sativus Seeds. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104487
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104487
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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