CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection
المؤلفون المشاركون
Jian-Hui, Chen
Er-Tao, Zhai
Si-Le, Chen
Hui, Wu
Kai-Ming, Wu
Chuang-Qi, Chen
Shi-Rong, Cai
Zhang, Xinhua
He, Yulong
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
CD44 and Sonic Hedgehog (Shh) signaling are important for gastric cancer (GC).
However, the clinical impact, survival, and recurrence outcome of CD44, Shh, and Gli1 expressions in GC patients following radical resection have not been elucidated.
Patients and Methods.
CD44, Shh, and Gli1 protein levels were quantified by immunohistochemistry (IHC).
The association between CD44, Shh, and Gli1 expression and clinicopathological features or prognosis of GC patients was determined.
The biomarker risk score was calculated by the IHC staining score of CD44, Shh, and Gli1 protein.
Results.
The IHC positive staining of CD44, Shh, and Gli1 proteins was correlated with larger tumour size, worse gross type and histological type, and advanced TNM stage, which also predicted shorter overall survival (OS) and disease-free survival (DFS) after radical resection.
Multivariate analysis indicated the Gli1 protein and Gli1, CD44 proteins were predictive biomarkers for OS and DFS, respectively.
If biomarker risk score was taken into analysis, it was the independent prognostic factor for OS and DFS.
Conclusions.
CD44 and Shh signaling are important biomarkers for tumour aggressiveness, survival, and recurrence in GC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jian-Hui, Chen& Er-Tao, Zhai& Si-Le, Chen& Hui, Wu& Kai-Ming, Wu& Zhang, Xinhua…[et al.]. 2015. CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104576
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jian-Hui, Chen…[et al.]. CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104576
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jian-Hui, Chen& Er-Tao, Zhai& Si-Le, Chen& Hui, Wu& Kai-Ming, Wu& Zhang, Xinhua…[et al.]. CD44, Sonic Hedgehog, and Gli1 Expression Are Prognostic Biomarkers in Gastric Cancer Patients after Radical Resection. Gastroenterology Research and Practice. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104576
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104576
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر