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Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis
المؤلفون المشاركون
Sun, Xiao-Dong
Huan, Chen
Qiu, Wei
Sun, Da-Wei
Shi, Xiao-Ju
Wang, Chuan-Lei
Jiang, Chao
Wang, Guang-Yi
Lv, Guo-Yue
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
Urothelial carcinoma-associated 1 (UCA1) has been reported to be overexpressed and correlated with progression in various cancers.
However, the association between UCA1 expression and some clinicopathological features of digestive system malignancies, such as metastasis and survival, remains inconclusive.
Therefore, a meta-analysis was performed to investigate the clinical significance of UCA1 in digestive system malignancies.
Methods.
Relevant literatures were searched in PubMed, Web of Science, Cochrane Library, and Embase databases updated to May 2016.
Results.
A total of 1089 patients from 10 studies were included in this meta-analysis.
Meta-analysis results showed that digestive system malignancy patients with UCA1 overexpression were significantly more susceptible to developing lymph node metastasis (LNM) (OR = 1.85, 95% CI: 1.28–2.67) and distant metastasis (DM) (OR = 3.14, 95% CI: 1.77–5.58) and suffer from poor overall survival (OS) (HR = 2.31, 95% CI: 1.89–2.82, univariate analysis; HR = 2.24, 95% CI: 1.69–2.98, multivariate analysis) and poor disease-free survival (DFS) (HR = 2.65, 95% CI: 1.59–4.43, univariate analysis; HR = 2.50, 95% CI: 1.62–3.86, multivariate analysis).
Conclusion.
UCA1 overexpression was correlated with LNM, DM, poor OS, and poor DFS.
UCA1 may serve as an indicator for metastasis and poor prognosis in digestive system malignancies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Xiao-Dong& Huan, Chen& Qiu, Wei& Sun, Da-Wei& Shi, Xiao-Ju& Wang, Chuan-Lei…[et al.]. 2016. Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104668
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Xiao-Dong…[et al.]. Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1104668
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Xiao-Dong& Huan, Chen& Qiu, Wei& Sun, Da-Wei& Shi, Xiao-Ju& Wang, Chuan-Lei…[et al.]. Clinical Significance of UCA1 to Predict Metastasis and Poor Prognosis of Digestive System Malignancies: A Meta-Analysis. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104668
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104668
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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