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Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers
المؤلفون المشاركون
Bănescu, Claudia
Voidăzan, Septimiu
Moldovan, Valeriu G.
Negovan, Anca
Iancu, Mihaela
Bataga, Simona
Pantea, Monica
Sarkany, Kinga
Tatar, Cristina
Mocan, Simona
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Aspirin use for cardiovascular or cancer prevention is limited due to its gastrointestinal side effects.
Objective.
Our prospective, observational case-control study aims to identify the predictive factors for ulcers in low-dose aspirin consumers (75–325 mg/day).
Methods.
The study included patients who underwent an upper digestive endoscopy and took low-dose aspirin treatment.
Results.
We recruited 51 patients with ulcer (ulcer group) and 108 patients with no mucosal lesions (control group).
In univariate analysis, factors significantly associated with ulcers were male gender ( p = 0.001 ), anticoagulants ( p = 0.029 ), nonsteroidal anti-inflammatory drugs ( p = 0.013 ), heart failure ( p = 0.007 ), liver ( p = 0.011 ) or cerebrovascular disease ( p = 0.004 ), diabetes mellitus ( p = 0.043 ), ulcer history ( p = 0.044 ), and alcohol consumption ( p = 0.018 ), but not Helicobacter pylori infection ( p = 0.2 ).
According to our multivariate regression analysis results, history of peptic ulcer (OR 3.07, 95% CI 1.06–8.86), cotreatment with NSAIDs (OR 8, 95% CI 2.09–30.58) or anticoagulants (OR 4.85, 95% CI 1.33–17.68), male gender (OR 5.2, 95% CI 1.77–15.34), and stroke (OR 7.27, 95% CI 1.40–37.74) remained predictors for ulcer on endoscopy.
Conclusions.
Concomitant use of NSAIDs or anticoagulants, comorbidities (cerebrovascular disease), and male gender are the most important independent risk factors for ulcer on endoscopy in low-dose aspirin consumers, in a population with a high prevalence of H.
pylori infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Negovan, Anca& Iancu, Mihaela& Moldovan, Valeriu G.& Voidăzan, Septimiu& Bataga, Simona& Pantea, Monica…[et al.]. 2016. Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers. Gastroenterology Research and Practice،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104771
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Negovan, Anca…[et al.]. Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers. Gastroenterology Research and Practice Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1104771
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Negovan, Anca& Iancu, Mihaela& Moldovan, Valeriu G.& Voidăzan, Septimiu& Bataga, Simona& Pantea, Monica…[et al.]. Clinical Risk Factors for Gastroduodenal Ulcer in Romanian Low-Dose Aspirin Consumers. Gastroenterology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104771
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104771
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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