Antiretroviral Resistance and Pregnancy Characteristics of Women with Perinatal and Nonperinatal HIV Infection
المؤلفون المشاركون
Money, Deborah
Mmeje, Okeoma
Fisher, Barbra M.
Aaron, Erika K.
Keating, Maria
Willers, Denise
Lazenby, Gweneth B.
Cohan, Deborah
Weinberg, Adriana
Luque, Amneris E.
المصدر
Infectious Diseases in Obstetrics and Gynecology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To compare HIV drug resistance in pregnant women with perinatal HIV (PHIV) and those with nonperinatal HIV (NPHIV) infection.
Methods.
We conducted a multisite cohort study of PHIV and NPHIV women from 2000 to 2014.
Sample size was calculated to identify a fourfold increase in antiretroviral (ARV) drug resistance in PHIV women.
Continuous variables were compared using Student’s t -test and Wilcoxon rank-sum tests.
Categorical variables were compared using χ 2 and Fisher’s exact tests.
Univariate analysis was used to determine factors associated with antiretroviral drug resistance.
Results.
Forty-one PHIV and 41 NPHIV participants were included.
Women with PHIV were more likely to have drug resistance than those with NPHIV ((55% versus 17%, p = 0.03 ), OR 6.0 (95% CI 1.0–34.8), p = 0.05 ), including multiclass resistance (15% versus 0, p = 0.03 ), and they were more likely to receive nonstandard ARVs during pregnancy (27% versus 5%, p = 0.01 ).
PHIV and NPHIV women had similar rates of preterm birth (11% versus 28%, p = 0.08 ) and cesarean delivery (47% versus 46%, p = 0.9 ).
Two infants born to a single NPHIV woman acquired HIV infection.
Conclusions.
PHIV women have a high frequency of HIV drug resistance mutations, leading to nonstandard ARVs use during pregnancy.
Despite nonstandard ARV use during pregnancy, PHIV women did not experience increased rates of adverse pregnancy outcomes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lazenby, Gweneth B.& Mmeje, Okeoma& Fisher, Barbra M.& Weinberg, Adriana& Aaron, Erika K.& Keating, Maria…[et al.]. 2016. Antiretroviral Resistance and Pregnancy Characteristics of Women with Perinatal and Nonperinatal HIV Infection. Infectious Diseases in Obstetrics and Gynecology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104869
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lazenby, Gweneth B.…[et al.]. Antiretroviral Resistance and Pregnancy Characteristics of Women with Perinatal and Nonperinatal HIV Infection. Infectious Diseases in Obstetrics and Gynecology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104869
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lazenby, Gweneth B.& Mmeje, Okeoma& Fisher, Barbra M.& Weinberg, Adriana& Aaron, Erika K.& Keating, Maria…[et al.]. Antiretroviral Resistance and Pregnancy Characteristics of Women with Perinatal and Nonperinatal HIV Infection. Infectious Diseases in Obstetrics and Gynecology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104869
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104869
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر