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Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes
المؤلفون المشاركون
Sumaoka, Jun
Akiba, Hiroki
Komiyama, Makoto
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Phosphorylation of tyrosine residues in proteins, as well as their dephosphorylation, is closely related to various diseases.
However, this phosphorylation is usually accompanied by more abundant phosphorylation of serine and threonine residues in the proteins and covers only 0.05% of the total phosphorylation.
Accordingly, highly selective detection of phosphorylated tyrosine in proteins is an urgent subject.
In this review, recent developments in this field are described.
Monomeric and binuclear T b I I I complexes, which emit notable luminescence only in the presence of phosphotyrosine (pTyr), have been developed.
There, the benzene ring of pTyr functions as an antenna and transfers its photoexcitation energy to the T b I I I ion as the emission center.
Even in the coexistence of phosphoserine (pSer) and phosphothreonine (pThr), pTyr can be efficintly detected with high selectivity.
Simply by adding these T b I I I complexes to the solutions, phosphorylation of tyrosine in peptides by protein tyrosine kinases and dephosphorylation by protein tyrosine phosphatases can be successfully visualized in a real-time fashion.
Furthermore, the activities of various inhibitors on these enzymes are quantitatively evaluated, indicating a strong potential of the method for efficient screening of eminent inhibitors from a number of candidates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sumaoka, Jun& Akiba, Hiroki& Komiyama, Makoto. 2016. Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes. International Journal of Analytical Chemistry،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1104937
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sumaoka, Jun…[et al.]. Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes. International Journal of Analytical Chemistry No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1104937
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sumaoka, Jun& Akiba, Hiroki& Komiyama, Makoto. Selective Sensing of Tyrosine Phosphorylation in Peptides Using Terbium(III) Complexes. International Journal of Analytical Chemistry. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1104937
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104937
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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