Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract
المؤلفون المشاركون
Chang, Yanxu
Li, Jin
Yu, Xie-an
Cao, Jun
An, Mingrui
Teye Azietaku, John
Hao, Jia
Tan, Zhijing
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A specific, sensitive, and reliable high performance liquid chromatography with fluorescence detection (HPLC-FLD) was first optimized and then used in the simultaneous quantification of bergapten, imperatorin, notopterol, and isoimperatorin in rat plasma using osthole as the internal standard.
Liquid-liquid extraction with ethyl acetate was employed in treating the rat plasma samples obtained.
Separation was carried out with a Hedera™ ODS column (4.6 × 250 mm, 5 μm) by gradient elution at a temperature of 40°C.
Excitation and emission of the fluorescence detector were set to 300 and 490 nm, respectively.
The lower limits of quantification for bergapten, imperatorin, notopterol, and isoimperatorin in rat plasma were 4, 40, 4, and 2 ng mL−1, respectively.
The intraday and interday precision and accuracy for the four coumarins were within acceptable criteria.
The recovery of the method was satisfactory with a range of 80.3–114%.
The validated method was successfully used for the simultaneous determination of the four coumarins in Notopterygium incisum extracts and also for the pharmacokinetic and excretion study of bergapten, imperatorin, notopterol, and isoimperatorin in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teye Azietaku, John& Yu, Xie-an& Li, Jin& Hao, Jia& Cao, Jun& An, Mingrui…[et al.]. 2016. Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract. International Journal of Analytical Chemistry،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104961
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teye Azietaku, John…[et al.]. Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract. International Journal of Analytical Chemistry No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104961
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teye Azietaku, John& Yu, Xie-an& Li, Jin& Hao, Jia& Cao, Jun& An, Mingrui…[et al.]. Simultaneous Determination of Bergapten, Imperatorin, Notopterol, and Isoimperatorin in Rat Plasma by High Performance Liquid Chromatography with Fluorescence Detection and Its Application to Pharmacokinetic and Excretion Study after Oral Administration of Notopterygium incisum Extract. International Journal of Analytical Chemistry. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104961
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104961
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر