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Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients
المؤلفون المشاركون
Hosny, Marwa M.
Sabek, Nagwan A.
El-Abaseri, Taghrid B.
Hassan, Fathalla M.
Farrag, Sherif H.
المصدر
International Journal of Breast Cancer
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Epigenetic modifications are involved in breast carcinogenesis.
Identifying genes that are epigenetically silenced via methylation could select target patients for diagnostic as well as therapeutic potential.
We assessed promoter methylation of breast cancer susceptibility gene 1 (BRCA1) and 17 Beta Hydroxysteroid Dehydrogenase Type 1 (17βHSD-1) in normal and cancer breast tissues of forty sporadic breast cancer (BC) cases using restriction enzyme based methylation-specific PCR (REMS-PCR).
In cancerous tissues, BRCA1 and 17βHSD-1 were methylated in 42.5% and 97.5%, respectively, while normal tissues had 35% and 95% methylation, respectively.
BRCA1 methylation in normal tissues was 12.2-fold more likely to associate with methylation in cancer tissues ( p < 0.001 ).
It correlated significantly with increased age at menopause, mitosis, the negative status of Her2, and the molecular subtype “luminal A” ( p = 0.048 , p = 0.042 , p = 0.007 , and p = 0.049 , resp.).
Methylation of BRCA1 and 17βHSD-1 related to luminal A subtype of breast cancer.
Since a small proportion of normal breast epithelial cells had BRCA1 methylation, our preliminary findings suggest that methylation of BRCA1 may be involved in breast tumors initiation and progression; therefore, it could be used as a biomarker for the early detection of sporadic breast cancer.
Methylation of 17βHSD-1 in normal and cancer tissue could save patients the long term use of adjuvant antiestrogen therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hosny, Marwa M.& Sabek, Nagwan A.& El-Abaseri, Taghrid B.& Hassan, Fathalla M.& Farrag, Sherif H.. 2016. Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. International Journal of Breast Cancer،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105404
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hosny, Marwa M.…[et al.]. Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. International Journal of Breast Cancer No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1105404
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hosny, Marwa M.& Sabek, Nagwan A.& El-Abaseri, Taghrid B.& Hassan, Fathalla M.& Farrag, Sherif H.. Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients. International Journal of Breast Cancer. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1105404
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105404
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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