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Differential Regulation of Morphology and Estrogen Receptor-Alpha Expression in the Vagina of Ovariectomized Adult Virgin Rats by Estrogen Replacement: A Histological Study
المؤلفون المشاركون
Li, Ting
Li, Ting
Ma, Yuanyuan
Zhang, Hong
Yan, Ping
Huo, Lili
Hu, Yongyan
Chen, Xi
Zhang, Miao
Liu, Zhaohui
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
To determine the exact role of estrogen in vaginal tissue morphology and estrogen receptor-alpha (ERα) distribution in the vagina, which remains controversial.
Methods.
Sixty rats were randomly categorized: sham-operated (sham), ovariectomy (OVX), and four estradiol treatments (estradiol valerate at 0.4, 0.8, 1.6, and 3.2 mg/kg/day) for 2 weeks.
Thereafter, vaginal samples were biopsied from the distal- and proximal-half portions.
The percentage of ERα-immunoreactive cells and the ERα score were quantified using immunohistochemistry to assess changes in ERα expression and distribution.
Results.
OVX induced significant vaginal atrophy and organic index.
Estrogen-replacement therapy (ERT) reversed vaginal atrophy.
The vaginal distal-half areas showed lower ERα% than the proximal-half areas.
The ERα% increased sharply 4 weeks after OVX, especially in the epithelial layer ( P = 0.023 ).
ERT elicited different degrees of reductions in tissues after the 2-week treatment, but the ERα% in only the epithelium recovered in parallel with that in the sham group ( P = 0.001 ).
The OVX group showed higher ERα histological scores than the sham group, and the distal-half area changed more evidently than the proximal-half area.
ERα expression was nearly unchanged after ERT ( P > 0.05 ).
Conclusions.
ERT is effective for treating obesity and vulvovaginal atrophy caused by hypoestrogenism and advancing age in menopausal women but cannot recover the distribution and expression of ERα.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Ting& Ma, Yuanyuan& Zhang, Hong& Yan, Ping& Huo, Lili& Hu, Yongyan…[et al.]. 2016. Differential Regulation of Morphology and Estrogen Receptor-Alpha Expression in the Vagina of Ovariectomized Adult Virgin Rats by Estrogen Replacement: A Histological Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Ting…[et al.]. Differential Regulation of Morphology and Estrogen Receptor-Alpha Expression in the Vagina of Ovariectomized Adult Virgin Rats by Estrogen Replacement: A Histological Study. International Journal of Endocrinology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Ting& Ma, Yuanyuan& Zhang, Hong& Yan, Ping& Huo, Lili& Hu, Yongyan…[et al.]. Differential Regulation of Morphology and Estrogen Receptor-Alpha Expression in the Vagina of Ovariectomized Adult Virgin Rats by Estrogen Replacement: A Histological Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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