Early Vascular Damage in Young Women with DM-1 and Its Relation to Anti-Müllerian Hormone: A Cross-Sectional Study
المؤلفون المشاركون
Verhaar, Marianne C.
de Kat, Annelien C.
Gremmels, Hendrik
Broekmans, Frank J. M.
Yarde, Felicia
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Vascular function is suggested to be associated with ovarian reserve, but the relationship with microvascular function has never been studied.
In this cross-sectional pilot study, the relationship of microvascular damage markers with AMH was studied in premenopausal women.
Twenty-two regularly cycling women with type 1 diabetes (DM-1) and a reference group of 20 healthy regularly cycling women were included, from whom blood was drawn in the early follicular phase of the menstrual cycle.
The main outcome was the correlation between circulating progenitor cells (CPCs), markers for early vascular damage, and AMH, a marker for ovarian reserve.
Secondary endpoints for early vascular impairment were circulating angiogenic cells and additional biomarkers.
Median AMH levels were 2.2 µg/L [1.2–3.5] in the DM-1 group and 2.1 µg/L [0.85–3.8] in the reference group.
CPCs were significantly decreased in women with DM-1; 1204 ± 537 CD34+/CD45dim cells were counted in the DM-1 group, compared to 2264 ± 1124 in the reference group.
CPCs and other markers of early vascular damage were not correlated with AMH levels in a multivariable analysis.
These results underscore previous findings of early vascular damage in DM-1 and suggest that there may not be a relationship between vascular function and ovarian reserve.
Trial Registration.
This trial is registered with Clinicaltrials.gov NCT01665716.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Kat, Annelien C.& Gremmels, Hendrik& Verhaar, Marianne C.& Broekmans, Frank J. M.& Yarde, Felicia. 2016. Early Vascular Damage in Young Women with DM-1 and Its Relation to Anti-Müllerian Hormone: A Cross-Sectional Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105760
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Kat, Annelien C.…[et al.]. Early Vascular Damage in Young Women with DM-1 and Its Relation to Anti-Müllerian Hormone: A Cross-Sectional Study. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105760
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Kat, Annelien C.& Gremmels, Hendrik& Verhaar, Marianne C.& Broekmans, Frank J. M.& Yarde, Felicia. Early Vascular Damage in Young Women with DM-1 and Its Relation to Anti-Müllerian Hormone: A Cross-Sectional Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105760
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105760
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر