![](/images/graphics-bg.png)
Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase IIIII Trial
المؤلفون المشاركون
Catalano, Maria Graziella
Pugliese, Mariateresa
Gallo, Marco
Brignardello, Enrico
Milla, Paola
Orlandi, Fabio
Limone, Paolo Piero
Boccuzzi, Giuseppe
Piovesan, Alessandro
Arvat, Emanuela
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Anaplastic thyroid cancer (ATC) has a median survival less than 5 months and, to date, no effective therapy exists.
Taxanes have recently been stated as the main drug treatment for ATC, and the histone deacetylase inhibitor valproic acid efficiently potentiates the effects of paclitaxel in vitro.
Based on these data, this trial assessed the efficacy and safety of the combination of paclitaxel and valproic acid for the treatment of ATC.
This was a randomized, controlled phase II/III trial, performed on 25 ATC patients across 5 centers in northwest Italy.
The experimental arm received the combination of paclitaxel (80 mg/m2/weekly) and valproic acid (1,000 mg/day); the control arm received paclitaxel alone.
Overall survival and disease progression, evaluated in terms of progression-free survival, were the primary outcomes.
The secondary outcome was the pharmacokinetics of paclitaxel.
The coadministration of valproic acid did not influence the pharmacokinetics of paclitaxel.
Neither median survival nor median time to progression was statistically different in the two arms.
Median survival of operated-on patients was significantly better than that of patients who were not operated on.
The present trial demonstrates that the addition of valproic acid to paclitaxel has no effect on overall survival and disease progression of ATC patients.
This trial is registered with EudraCT 2008-005221-11.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Catalano, Maria Graziella& Pugliese, Mariateresa& Gallo, Marco& Brignardello, Enrico& Milla, Paola& Orlandi, Fabio…[et al.]. 2016. Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase IIIII Trial. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105832
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Catalano, Maria Graziella…[et al.]. Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase IIIII Trial. International Journal of Endocrinology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105832
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Catalano, Maria Graziella& Pugliese, Mariateresa& Gallo, Marco& Brignardello, Enrico& Milla, Paola& Orlandi, Fabio…[et al.]. Valproic Acid, a Histone Deacetylase Inhibitor, in Combination with Paclitaxel for Anaplastic Thyroid Cancer: Results of a Multicenter Randomized Controlled Phase IIIII Trial. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105832
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105832
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)