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Interaction between Angiotensin II and InsulinIGF-1 Exerted a Synergistic Stimulatory Effect on ERK12 Activation in Adrenocortical Carcinoma H295R Cells
المؤلفون المشاركون
Tong, An-li
Wang, Fen
Cui, Yun-ying
Li, Chun-yan
Li, Yu-xiu
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-12
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The cross talk between angiotensin II (Ang II) and insulin has been described mainly in cardiovascular cells, hepatocytes, adipocytes, and so forth, and to date no such cross talk was reported in adrenal.
In this study, we examined the interaction between Ang II and insulin/IGF-1 in ERK and AKT signaling pathways and expression of steroidogenic enzymes in H295R cells.
Compared to the control, 100 nM Ang II increased phospho-ERK1/2 approximately 3-fold.
Insulin (100 nM) or IGF-1 (10 nM) alone raised phospho-ERK1/2 1.8- and 1.5-fold, respectively, while, after pretreatment with 100 nM Ang II for 30 min, insulin (100 nM) or IGF-1 (10 nM) elevated phospho-ERK1/2 level 8- and 7-fold, respectively.
The synergistic effect of Ang II and insulin/IGF-1 on ERK1/2 activation was inhibited by selective AT1 receptor blocker, PKC inhibitor, and MEK1/2 inhibitor.
Ang II marginally suppressed AKT activation under the basal condition, while it had no effect on phospho-AKT induced by insulin/IGF-1.
Ang II significantly stimulated mRNA expression of CYP11B1 and CYP11B2, and such stimulatory effects were enhanced when cells were cotreated with insulin/IGF-1.
We are led to conclude that Ang II in combination with insulin/IGF-1 had an evident synergistic stimulatory effect on ERK1/2 activation in H295R cells and the effect may be responsible for the enhanced steroid hormone production induced by Ang II plus insulin/IGF-1.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tong, An-li& Wang, Fen& Cui, Yun-ying& Li, Chun-yan& Li, Yu-xiu. 2016. Interaction between Angiotensin II and InsulinIGF-1 Exerted a Synergistic Stimulatory Effect on ERK12 Activation in Adrenocortical Carcinoma H295R Cells. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105852
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tong, An-li…[et al.]. Interaction between Angiotensin II and InsulinIGF-1 Exerted a Synergistic Stimulatory Effect on ERK12 Activation in Adrenocortical Carcinoma H295R Cells. International Journal of Endocrinology No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1105852
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tong, An-li& Wang, Fen& Cui, Yun-ying& Li, Chun-yan& Li, Yu-xiu. Interaction between Angiotensin II and InsulinIGF-1 Exerted a Synergistic Stimulatory Effect on ERK12 Activation in Adrenocortical Carcinoma H295R Cells. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1105852
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105852
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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