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Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats
المؤلفون المشاركون
Ünübol, Mustafa
Güney, Engin
Demir, Şule
Aypak, Serap Ünübol
İpek, Emrah
Aktaş, Serdar
Ekren, Gamze Sevri
Yılmaz, Murat
Tunca, Recai
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-07
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
It is speculated that thyroid hormones may be involved in nonalcoholic fatty liver disease (NAFLD) pathogenesis.
A literature scan, however, demonstrated conflicting results from studies investigating the relationship between hypothyroidism and NAFLD.
Therefore, our study aims to evaluate NAFLD, from the histopathologic perspective, in hypothyroidism-induced rats.
Wistar rats were divided into 2 groups: the experimental group consumed water containing methimazole 0.025% (MMI, Sigma, USA) for 12 weeks and the control group consumed tap water.
At the end of week 12, serum glucose, ALT, AST, triglyceride, HDL, LDL, TSH, fT4, fT3, visfatin, and insulin assays were performed.
Sections were stained with hematoxylin-eosin and “Oil Red-O” for histopathologic examination of the livers.
In our study, we detected mild hepatosteatosis in all hypothyroidism-induced rats.
There was statistically significant difference with respect to obesity between the two groups ( p < 0.001 ).
The mean fasting blood glucose was 126.25 ± 23.4 mg/dL in hypothyroidism-induced group and 102.63 ± 15.51 mg/dL in the control group, with a statistically significant difference between the groups ( p = 0.032 ).
The two groups did not differ statistically significantly with respect to visfatin levels ( p > 0.05 ).
In conclusion, we found that hypothyroidism-induced rats had mild hepatosteatosis as opposed to the control group histopathologically.
Our study indicates that hypothyroidism can cause NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Demir, Şule& Ünübol, Mustafa& Aypak, Serap Ünübol& İpek, Emrah& Aktaş, Serdar& Ekren, Gamze Sevri…[et al.]. 2016. Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105903
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Demir, Şule…[et al.]. Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105903
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Demir, Şule& Ünübol, Mustafa& Aypak, Serap Ünübol& İpek, Emrah& Aktaş, Serdar& Ekren, Gamze Sevri…[et al.]. Histopathologic Evaluation of Nonalcoholic Fatty Liver Disease in Hypothyroidism-Induced Rats. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105903
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105903
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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