Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease
المؤلفون المشاركون
Arpaci, Dilek
Köktürk, Füruzan
Can, Murat
Kuzu, Fatih
Unal, Mustafa
Altas, Ayfer
Haytaoglu, Gürkan
Ilikhan, Sevil Uygun
Bayraktaroglu, Taner
Barut, Figen
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Midkine (MK), a new heparin-binding growth factor, plays important roles in a variety of biological phenomena such as carcinogenesis, inflammation, and angiogenesis.
In this study, we aimed to evaluate serum midkine (SMK) and nodular midkine (NMK) levels in patients with thyroid nodules to predict malignancy and whether there was any association between.
Methods.
A total of 105 patients (74 women, 31 men) with thyroid nodules were enrolled.
The levels of SMK and NMK were measured.
Any possible correlation between SMK, NMK, and biochemical, cytopathological, or radiological variables was investigated.
Results.
Both SMK and NMK were found to be higher in hypoechoic nodules with an irregular border and without a halo ( p < 0.05 ).
Serum MK levels were significantly higher in nodules with microcalcifications than nodules with macrocalcification or without calcification ( p = 0.001 ).
SMK levels were found to be correlated with NMK levels (SMK 0.63 ng/ml versus 1.04 ng/mL and NMK 0.55 ng/mL versus 0.55 ng/mL, r 2 = 0.54 , p < 0.001 ).
Conclusion.
Both SMK and NMK can predict tumorigenesis of highly malignant/suspicious thyroid cytopathology and also well correlated with sonographic features of thyroid nodules.
We suggest that MK levels may serve as an alternative biomarker, in conjunction with the cytopathological results in preoperative assessment of thyroid nodules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kuzu, Fatih& Arpaci, Dilek& Unal, Mustafa& Altas, Ayfer& Haytaoglu, Gürkan& Can, Murat…[et al.]. 2016. Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105933
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kuzu, Fatih…[et al.]. Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105933
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kuzu, Fatih& Arpaci, Dilek& Unal, Mustafa& Altas, Ayfer& Haytaoglu, Gürkan& Can, Murat…[et al.]. Midkine: A Novel Biomarker to Predict Malignancy in Patients with Nodular Thyroid Disease. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105933
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105933
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر