Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells
المؤلفون المشاركون
Richard, Derek J.
Li, Huika
Pham, Thy
McWhinney, Brett C.
Ungerer, Jacobus P.
Pretorius, Carel J.
Mortimer, Robin H.
d’Emden, Michael C.
Richard, Kerry
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Sex Hormone Binding Globulin (SHBG) is the major serum carrier of sex hormones.
However, growing evidence suggests that SHBG is internalised and plays a role in regulating intracellular hormone action.
This study was to determine whether SHBG plays a role in testosterone uptake, metabolism, and action in the androgen sensitive LNCaP prostate cancer cell line.
Internalisation of SHBG and testosterone, the effects of SHBG on testosterone uptake, metabolism, regulation of androgen responsive genes, and cell growth were assessed.
LNCaP cells internalised SHBG by a testosterone independent process.
Testosterone was rapidly taken up and effluxed as testosterone-glucuronide; however this effect was reduced by the presence of SHBG.
Addition of SHBG, rather than reducing testosterone bioavailability, further increased testosterone-induced expression of prostate specific antigen and enhanced testosterone-induced reduction of androgen receptor mRNA expression.
Following 38 hours of testosterone treatment cell morphology changed and growth declined; however, cotreatment with SHBG abrogated these inhibitory effects.
These findings clearly demonstrate that internalised SHBG plays an important regulatory and intracellular role in modifying testosterone action and this has important implications for the role of SHBG in health and disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Huika& Pham, Thy& McWhinney, Brett C.& Ungerer, Jacobus P.& Pretorius, Carel J.& Richard, Derek J.…[et al.]. 2016. Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1105952
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Huika…[et al.]. Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells. International Journal of Endocrinology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1105952
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Huika& Pham, Thy& McWhinney, Brett C.& Ungerer, Jacobus P.& Pretorius, Carel J.& Richard, Derek J.…[et al.]. Sex Hormone Binding Globulin Modifies Testosterone Action and Metabolism in Prostate Cancer Cells. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1105952
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105952
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر