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Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation
المؤلفون المشاركون
Mikami, Shuji
Nishimoto, Koshiro
Seki, Tsugio
Hayashi, Yuichiro
Al-Eyd, Ghaith
Nakagawa, Ken
Morita, Shinya
Kosaka, Takeo
Oya, Mototsugu
Mitani, Fumiko
Suematsu, Makoto
Kabe, Yasuaki
Mukai, Kuniaki
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
The immunohistochemical detection of aldosterone synthase (CYP11B2) and steroid 11β-hydroxylase (CYP11B1) has enabled the identification of aldosterone-producing cell clusters (APCCs) in the subcapsular portion of the human adult adrenal cortex.
We hypothesized that adrenals have layered zonation in early postnatal stages and are remodeled to possess APCCs over time.
Purposes.
To investigate changes in human adrenocortical zonation with age.
Methods.
We retrospectively analyzed adrenal tissues prepared from 33 autopsied patients aged between 0 and 50 years.
They were immunostained for CYP11B2 and CYP11B1.
The percentage of APCC areas over the whole adrenal area (AA/WAA, %) and the number of APCCs (NOA, APCCs/mm2) were calculated by four examiners.
Average values were used in statistical analyses.
Results.
Adrenals under 11 years old had layered zona glomerulosa (ZG) and zona fasciculata (ZF) without apparent APCCs.
Some adrenals had an unstained (CYP11B2/CYP11B1-negative) layer between ZG and ZF, resembling the rat undifferentiated cell zone.
Average AA/WAA and NOA correlated with age, suggesting that APCC development is associated with aging.
Possible APCC-to-APA transitional lesions were incidentally identified in two adult adrenals.
Conclusions.
The adrenal cortex with layered zonation remodels to possess APCCs over time.
APCC generation may be associated with hypertension in adults.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nishimoto, Koshiro& Seki, Tsugio& Hayashi, Yuichiro& Mikami, Shuji& Al-Eyd, Ghaith& Nakagawa, Ken…[et al.]. 2016. Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105995
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nishimoto, Koshiro…[et al.]. Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1105995
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nishimoto, Koshiro& Seki, Tsugio& Hayashi, Yuichiro& Mikami, Shuji& Al-Eyd, Ghaith& Nakagawa, Ken…[et al.]. Human Adrenocortical Remodeling Leading to Aldosterone-Producing Cell Cluster Generation. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105995
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1105995
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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