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NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats
المؤلفون المشاركون
Wenhong, Deng
Weixing, Wang
Abliz, Ablikim
Chen, Chen
Sun, Rongze
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-07
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
PCBs, widespread endocrine disruptors, cause the disturbance of thyroid hormone (TH) homeostasis in humans and animals.
However, the exact mechanism of thyroid dysfunction caused by PCBs is still unknown.
In order to clarify the hypotheses that NADPH oxidase (NOX) and subsequent NF-κB pathway may play roles in thyroid dysfunction, sixty Sprague-Dawley rats were randomly divided into four groups: control group, PCB153 treated (PCB) group, received apocynin with PCB153 treatment (APO + PCB) group, and drug control (APO) group.
Serum thyroid hormone levels were evaluated.
The morphological change of thyroid tissue was analyzed under the light and transmission electron microscopy.
NOX2, 8-OHdG, and NF-κB expression in the thyroid tissue was evaluated by immune-histochemical staining.
Oxidative stress and inflammatory cytokines were detected.
The following results were reduced after apocynin treatment: (1) serum thyroid hormone, (2) thyroid pathological injuries, (3) thyroid MDA, (4) thyroid ultrastructural change, (5) serum inflammatory cytokines, and (6) thyroid expression of NOX2, 8-OHdG, and NF-κB.
These results suggested that NOX inhibition attenuates thyroid dysfunction induced by PCB in rats, presumably because of its role in preventing ROS generation and inhibiting the activation of NF-κB pathway.
Our findings may provide new therapeutic targets for PCBs induced thyroid dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abliz, Ablikim& Chen, Chen& Wenhong, Deng& Weixing, Wang& Sun, Rongze. 2016. NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106009
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abliz, Ablikim…[et al.]. NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats. International Journal of Endocrinology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1106009
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abliz, Ablikim& Chen, Chen& Wenhong, Deng& Weixing, Wang& Sun, Rongze. NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106009
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106009
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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