Maternal Diet Supplementation with n-6n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice
المؤلفون المشاركون
Visentainer, J. V.
Barella, Luiz Felipe
Martin, Josiane Morais
Miranda, Rosiane Aparecida
Palma-Rigo, Kesia
Alves, Vander Silva
Fabricio, Gabriel Sergio
Pavanello, Audrei
Franco, Claudinéia Conationi da Silva
Ribeiro, Tatiane Aparecida
Banafé, Elton Guntendeorfer
Martin, Clayton Antunes
de Oliveira, Júlio Cezar
de Freitas Mathias, Paulo Cezar
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Essential polyunsaturated fatty acids (PUFAs) prevent cardiometabolic diseases.
We aimed to study whether a diet supplemented with a mixture of n-6/n-3 PUFAs, during perinatal life, attenuates outcomes of long-term metabolic dysfunction in prediabetic and obese mice.
Seventy-day-old virgin female mice were mated.
From the conception day, dams were fed a diet supplemented with sunflower oil and flaxseed powder (containing an n-6/n-3 PUFAs ratio of 1.2 : 1.0) throughout pregnancy and lactation, while control dams received a commercial diet.
Newborn mice were treated with monosodium L-glutamate (MSG, 4 mg g−1 body weight per day) for the first 5 days of age.
A batch of weaned pups was sacrificed to quantify the brain and pancreas total lipids; another batch were fed a commercial diet until 90 days of age, where glucose homeostasis and glucose-induced insulin secretion (GIIS) as well as retroperitoneal fat and Lee index were assessed.
MSG-treated mice developed obesity, glucose intolerance, insulin resistance, pancreatic islet dysfunction, and higher fat stores.
Maternal flaxseed diet-supplementation decreased n-6/n-3 PUFAs ratio in the brain and pancreas and blocked glucose intolerance, insulin resistance, GIIS impairment, and obesity development.
The n-6/n-3 essential PUFAs in a ratio of 1.2 : 1.0 supplemented in maternal diet during pregnancy and lactation prevent metabolic dysfunction in MSG-obesity model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Martin, Josiane Morais& Miranda, Rosiane Aparecida& Barella, Luiz Felipe& Palma-Rigo, Kesia& Alves, Vander Silva& Fabricio, Gabriel Sergio…[et al.]. 2016. Maternal Diet Supplementation with n-6n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106048
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Martin, Josiane Morais…[et al.]. Maternal Diet Supplementation with n-6n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice. International Journal of Endocrinology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106048
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Martin, Josiane Morais& Miranda, Rosiane Aparecida& Barella, Luiz Felipe& Palma-Rigo, Kesia& Alves, Vander Silva& Fabricio, Gabriel Sergio…[et al.]. Maternal Diet Supplementation with n-6n-3 Essential Fatty Acids in a 1.2 : 1.0 Ratio Attenuates Metabolic Dysfunction in MSG-Induced Obese Mice. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106048
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106048
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر