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Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies
المؤلفون المشاركون
Senthilkumaran, Manjula
Zhou, Xin-Fu
Bobrovskaya, Larisa
المصدر
International Journal of Endocrinology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-23
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Recurrent insulin-induced hypoglycaemia is a major limitation to insulin treatment in diabetes patients leading to a condition called hypoglycaemia-associated autonomic failure (HAAF).
HAAF is characterised by reduced sympathoadrenal response to subsequent hypoglycaemia thereby predisposing the patients to severe hypoglycaemia that can lead to coma or even death.
Despite several attempts being made, the mechanism of HAAF is yet to be clearly established.
In order for the mechanism of HAAF to be elucidated, establishing a human/animal model of the phenomenon is the foremost requirement.
Several research groups have attempted to reproduce the phenomenon in diabetic and nondiabetic humans and rodents and reported variable results.
The success of the phenomenon is marked by a significant reduction in plasma adrenaline response to subsequent hypoglycaemic episode relative to that of the antecedent hypoglycaemic episode.
A number of factors such as the insulin dosage, route of administration, fasting conditions, blood sampling methods and analyses, depth, duration, and number of antecedent hypoglycaemic episodes can impact the successful reproduction of the phenomenon and thus have to be carefully considered while developing the protocol.
In this review, we have outlined the protocols followed by different research groups to reproduce the phenomenon in diabetic and nondiabetic humans and rodents including our own observations in rats and discussed the factors that have to be given careful consideration in reproducing the phenomenon successfully.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Senthilkumaran, Manjula& Zhou, Xin-Fu& Bobrovskaya, Larisa. 2016. Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Senthilkumaran, Manjula…[et al.]. Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies. International Journal of Endocrinology No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1106057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Senthilkumaran, Manjula& Zhou, Xin-Fu& Bobrovskaya, Larisa. Challenges in Modelling Hypoglycaemia-Associated Autonomic Failure: A Review of Human and Animal Studies. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1106057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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