Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats
المؤلف
المصدر
International Journal of Inflammation
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-11
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Nicotine is protective in ulcerative colitis but not Crohn’s disease of the small intestine, but little is known about the effects of nicotine on Clostridium difficile toxin A-induced enteritis.
Isolated ileal or colonic segments in anesthetized rats were pretreated with nicotine bitartrate or other pharmacological agents before intraluminal injection of toxin A.
After 3 hours, the treated segments were removed and inflammation was assessed.
Nicotine biphasically inhibited toxin A colitis but not ileitis.
Pretreatment with the nicotinic receptor antagonist, hexamethonium, blocked the effects of nicotine.
Pretreating the colonic segments with hexamethonium before toxin A administration resulted in more inflammation than seen with toxin A alone, suggesting that a tonic nicotinic anti-inflammatory condition exists in the colon.
Nicotine also inhibited toxin A-induced increased colonic concentrations of the TRPV1 (transient receptor potential vanilloid subtype 1) agonist, leukotriene B4 (LTB4), and release of the proinflammatory neuropeptide, substance P.
Pretreatment with nicotine did not protect against direct TRPV1-mediated colitis caused by intraluminal capsaicin.
Nicotinic cholinergic receptors tonically protect the colon against inflammation and nicotine inhibits toxin A colitis but not toxin A ileitis in rats in part by inhibition of toxin A-induced activation of TRPV1 by endogenous TRPV1 agonists such as LTB4.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vigna, Steven R.. 2016. Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats. International Journal of Inflammation،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vigna, Steven R.. Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats. International Journal of Inflammation No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vigna, Steven R.. Nicotine Inhibits Clostridium difficile Toxin A-Induced Colitis but Not Ileitis in Rats. International Journal of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر