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Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy
المؤلفون المشاركون
Wang, Cheng-Zhi
Kazmierczak, Robert A.
Eisenstark, Abraham
المصدر
International Journal of Microbiology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Recently, investigation of bacterial-based tumor therapy has regained focus due to progress in molecular, cellular, and microbial biology.
Many bacteria such as Salmonella, Listeria, Escherichia, and Clostridium have proved to have tumor targeting and in some cases even tumor-destroying phenotypes.
Furthermore, bacterial clinical treatments for cancer have been improved by combination with other therapeutic methods such as chemotherapeutic drugs and radioactive agents.
Synthetic biology techniques have also driven the development of new bacterial-based cancer therapies.
However, basic questions about the mechanisms of bacterial-mediated tumor targeting and destruction are still being elucidated.
In this review, we focus on three tumor-therapeutic Salmonella models, the most intensively studied bacterial genus in this field.
One of these Salmonella models is our Salmonella enterica serovar Typhimurium LT2 derived strain CRC2631, engineered to minimize toxicity but maximize tumor-targeting and destruction effects.
The other two are VNP20009 and A1-R.
We compare the means by which these therapeutic candidate strain models were selected for study, their tumor targeting and tumor destruction phenotypes in vitro and in vivo, and what is currently known about the mechanisms by which they target and destroy tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Cheng-Zhi& Kazmierczak, Robert A.& Eisenstark, Abraham. 2016. Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy. International Journal of Microbiology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106276
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Cheng-Zhi…[et al.]. Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy. International Journal of Microbiology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1106276
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Cheng-Zhi& Kazmierczak, Robert A.& Eisenstark, Abraham. Strains, Mechanism, and Perspective: Salmonella-Based Cancer Therapy. International Journal of Microbiology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1106276
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106276
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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