![](/images/graphics-bg.png)
Erythropoietin Dose and Mortality in Hemodialysis Patients: Marginal Structural Model to Examine Causality
المؤلفون المشاركون
Arah, Onyebuchi A.
Kalantar-Zadeh, Kamyar
Streja, Elani
Park, Jongha
Chan, Ting-Yan
Lee, Janet
Soohoo, Melissa
Rhee, Connie M.
المصدر
International Journal of Nephrology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
It has been previously reported that a higher erythropoiesis stimulating agent (ESA) dose in hemodialysis patients is associated with adverse outcomes including mortality; however the causal relationship between ESA and mortality is still hotly debated.
We hypothesize ESA dose indeed exhibits a direct linear relationship with mortality in models of association implementing the use of a marginal structural model (MSM), which controls for time-varying confounding and examines causality in the ESA dose-mortality relationship.
We conducted a retrospective cohort study of 128 598 adult hemodialysis patients over a 5-year follow-up period to evaluate the association between weekly ESA (epoetin-α) dose and mortality risk.
A MSM was used to account for baseline and time-varying covariates especially laboratory measures including hemoglobin level and markers of malnutrition-inflammation status.
There was a dose-dependent positive association between weekly epoetin-α doses ≥18 000 U/week and mortality risk.
Compared to ESA dose of <6 000 U/week, adjusted odds ratios (95% confidence interval) were 1.02 (0.94–1.10), 1.08 (1.00–1.18), 1.17 (1.06–1.28), 1.27 (1.15–1.41), and 1.52 (1.37–1.69) for ESA dose of 6 000 to <12 000, 12 000 to <18 000, 18 000 to <24 000, 24 000 to <30 000, and ≥30 000 U/week, respectively.
High ESA dose may be causally associated with excessive mortality, which is supportive of guidelines which advocate for conservative management of ESA dosing regimen in hemodialysis patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Streja, Elani& Park, Jongha& Chan, Ting-Yan& Lee, Janet& Soohoo, Melissa& Rhee, Connie M.…[et al.]. 2016. Erythropoietin Dose and Mortality in Hemodialysis Patients: Marginal Structural Model to Examine Causality. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Streja, Elani…[et al.]. Erythropoietin Dose and Mortality in Hemodialysis Patients: Marginal Structural Model to Examine Causality. International Journal of Nephrology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Streja, Elani& Park, Jongha& Chan, Ting-Yan& Lee, Janet& Soohoo, Melissa& Rhee, Connie M.…[et al.]. Erythropoietin Dose and Mortality in Hemodialysis Patients: Marginal Structural Model to Examine Causality. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)