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Matrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review
المؤلفون المشاركون
Kousios, Andreas
Kouis, Panayiotis
Panayiotou, Andrie G.
المصدر
International Journal of Nephrology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Cardiovascular disease (CVD) remains a significant problem in Chronic Kidney Disease (CKD).
Subclinical atherosclerosis identified by noninvasive methods could improve CVD risk prediction in CKD but these methods are often unavailable.
We therefore systematically reviewed whether circulating levels of Matrix Metalloproteinases (MMPs) and tissue inhibitors (TIMPs) are associated with subclinical atherosclerosis in CKD, as this would support their use as biomarkers or pharmacologic targets.
Methods.
All major electronic databases were systematically searched from inception until May 2015 using appropriate terms.
Studies involving CKD patients with data on circulating MMPs levels and atherosclerosis were considered and subjected to quality assessment.
Results.
Overall, 16 studies were identified for qualitative synthesis and 9 studies were included in quantitative synthesis.
MMP-2 and TIMP-1 were most frequently studied while most studies assessed carotid Intima-Media Thickness (cIMT) as a measure of subclinical atherosclerosis.
Only MMP-2 demonstrated a consistent positive association with cIMT.
Considerable variability in cIMT measurement methodology and poor plaque assessment was found.
Conclusions.
Although MMPs demonstrate great potential as biomarkers of subclinical atherosclerosis, they are understudied in CKD and not enough data existed for meta-analysis.
Larger studies involving several MMPs, with more homogenized approaches in determining the atherosclerotic burden in CKD, are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kousios, Andreas& Kouis, Panayiotis& Panayiotou, Andrie G.. 2016. Matrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106358
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kousios, Andreas…[et al.]. Matrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review. International Journal of Nephrology No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1106358
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kousios, Andreas& Kouis, Panayiotis& Panayiotou, Andrie G.. Matrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1106358
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106358
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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