Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit
المؤلفون المشاركون
Abdel-Latif, Mohamed E.
Singh, Natasha
Dhayade, Aparna
Chaudhari, Tejasvi Vasant
المصدر
International Journal of Pediatrics
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-21
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background and Objectives.
Antacids are often prescribed to preterm infants due to misdiagnosis of gastro-oesophageal reflux.
This suppresses gastric acidity, a major defence mechanism against infection.
This study aims to determine if ranitidine and omeprazole use in very low birth weight (VLBW) neonates, <1500 grams, is associated with increased risk of late onset sepsis, necrotising enterocolitis (NEC), and mortality.
Methods.
Retrospective analysis was conducted on neonates, <1500 grams, born and admitted into the Neonatal Intensive Care Unit at The Canberra Hospital during the period from January 2008 to December 2012.
Information regarding late onset sepsis, NEC, mortality, ranitidine/omeprazole use, and other neonatal/hospital factors was collected for each neonate.
Results.
360 neonates were evaluated, 64 received ranitidine and/or omeprazole, and 296 had not.
There were no statistically significant differences in incidence of late onset sepsis (OR = 0.52, CI = 0.24–1.1, and p = 0.117), NEC Stage 2 and above (OR = 0.4, CI = 0.05–3.2, and p = 0.7), or mortality (OR = 0.35, CI = 0.08–1.5, and p = 0.19) between the two groups.
After adjusting significant differences in neonatal and hospital factors, risk of late onset sepsis was significantly lower in those that received ranitidine/omeprazole (OR = 0.28, CI = 0.13–0.65, and p = 0.003).
Conclusions.
Ranitidine and omeprazole use in VLBW preterm infants may not be associated with an increased risk of infection, NEC, and mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Natasha& Dhayade, Aparna& Abdel-Latif, Mohamed E.& Chaudhari, Tejasvi Vasant. 2016. Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit. International Journal of Pediatrics،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106590
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Natasha…[et al.]. Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit. International Journal of Pediatrics No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106590
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Natasha& Dhayade, Aparna& Abdel-Latif, Mohamed E.& Chaudhari, Tejasvi Vasant. Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit. International Journal of Pediatrics. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106590
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106590
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر