Preparation and Characterization of Irinotecan Loaded Cross-Linked Bovine Serum Albumin Beads for Liver Cancer Chemoembolization Therapy
المؤلفون المشاركون
Yan, Jin
Wang, Fei
Chen, Jun
Liu, Tao
Zhang, Tao
المصدر
International Journal of Polymer Science
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
In this paper, a novel temporary embolization agent for transarterial chemoembolization of liver cancer was developed and tested.
The Irinotecan loaded bovine serum albumin (BSA) beads were tried to be used as embolic agent of liver cancer therapy.
BSA beads were prepared by a water-in-oil emulsion solvent diffusion method in soya oil and Span 85 was used as the emulsifier.
The obtained BSA beads were able to swell 2.37-fold comparing to dried beads.
Depending on the equilibrium swelling process, the Irinotecan was loaded with 9.8% total drug concentration and tested.
In vitro drug release studies showed that a burst release of Irinotecan was achieved.
Eventually BSA beads were completely degraded in a few weeks.
CCK-8 assay demonstrated that BSA beads showed no cytotoxicity against human umbilical vein endothelial cells, and the Irinotecan loaded BSA beads showed comparable cytotoxicity against Hep G2, a human liver carcinoma cell line, as the traditional Irinotecan.
In a rabbit model, it was found that BSA beads can successfully be transferred to liver and provide occlusion of small arteries.
The present investigation suggested that the BSA beads are promising drug carriers and can potentially be used as temporary embolization agents in interventional oncology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yan, Jin& Wang, Fei& Chen, Jun& Liu, Tao& Zhang, Tao. 2016. Preparation and Characterization of Irinotecan Loaded Cross-Linked Bovine Serum Albumin Beads for Liver Cancer Chemoembolization Therapy. International Journal of Polymer Science،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yan, Jin…[et al.]. Preparation and Characterization of Irinotecan Loaded Cross-Linked Bovine Serum Albumin Beads for Liver Cancer Chemoembolization Therapy. International Journal of Polymer Science No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yan, Jin& Wang, Fei& Chen, Jun& Liu, Tao& Zhang, Tao. Preparation and Characterization of Irinotecan Loaded Cross-Linked Bovine Serum Albumin Beads for Liver Cancer Chemoembolization Therapy. International Journal of Polymer Science. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1106896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر