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High-Throughput Analysis of Lidocaine in Pharmaceutical Formulation by Capillary Zone Electrophoresis Using Multiple Injections in a Single Run
المؤلفون المشاركون
Valese, Andressa C.
Spudeit, Daniel A.
Dolzan, Maressa D.
Bretanha, Lizandra C.
Vitali, Luciano
Micke, Gustavo A.
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-16
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This paper reports the development of a subminute separation method by capillary zone electrophoresis in an uncoated capillary using multiple injection procedure for the determination of lidocaine in samples of pharmaceutical formulations.
The separation was performed in less than a minute leading to doing four injections in a single run.
The cathodic electroosmotic flow contributed to reducing the analyses time.
The background electrolyte was composed of 20 mmol L−1 2-amino-2-(hydroxymethyl)-1,3-propanediol and 40 mmol L−1 2-(N-morpholino)ethanesulfonic acid at pH 6.1.
The internal standard used was benzylamine.
Separations were performed in a fused uncoated silica capillary (32 cm total length, 23.5 cm effective length, and 50 μm internal diameter) with direct UV detection at 200 nm.
Samples and standards were injected hydrodynamically using 40 mbar/3 s interspersed with spacer electrolyte using 40 mbar/7 s.
The electrophoretic system was operated under constant voltage of 30 kV with positive polarity on the injection side.
The evaluation of some analytical parameters of the method showed good linearity ( r 2 > 0.999 ) , a limit of detection 0.92 mg L−1, intermediate precision better than 3.2% (peak area), and recovery in the range of 92–102%.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Valese, Andressa C.& Spudeit, Daniel A.& Dolzan, Maressa D.& Bretanha, Lizandra C.& Vitali, Luciano& Micke, Gustavo A.. 2016. High-Throughput Analysis of Lidocaine in Pharmaceutical Formulation by Capillary Zone Electrophoresis Using Multiple Injections in a Single Run. Journal of Analytical Methods in Chemistry،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107311
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Valese, Andressa C.…[et al.]. High-Throughput Analysis of Lidocaine in Pharmaceutical Formulation by Capillary Zone Electrophoresis Using Multiple Injections in a Single Run. Journal of Analytical Methods in Chemistry No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1107311
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Valese, Andressa C.& Spudeit, Daniel A.& Dolzan, Maressa D.& Bretanha, Lizandra C.& Vitali, Luciano& Micke, Gustavo A.. High-Throughput Analysis of Lidocaine in Pharmaceutical Formulation by Capillary Zone Electrophoresis Using Multiple Injections in a Single Run. Journal of Analytical Methods in Chemistry. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1107311
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107311
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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