Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major
المؤلفون المشاركون
Pes, Gianni
Tolu, Francesco
Dore, Maria Pina
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Intensive transfusion schedule and iron-chelating therapy prolonged and improved quality of life in patients with β-thalassemia (β-T) major.
However, this led to an increased risk of developing impaired glucose tolerance or diabetes.
In this study we analyzed variables associated with the occurrence of impaired glucose tolerance or diabetes in patients with β-T major.
Methods.
388 Sardinian patients were included.
Age, gender, duration of chelation therapy, body mass index, and markers of pancreatic and extrapancreatic autoimmunity were analyzed.
Results.
Multiple logistic regression analysis showed that anti-thyroid peroxidase (TPO) antibodies (Ab) (OR = 3.36; p = 0.008 ) and male gender (OR = 1.98; p = 0.025 ) were significantly associated with glucose impairment, while the other variables were not.
Ferritin levels were significantly higher in TPOAb positive compared to TPOAb negative patients (4870 ± 1665 μg/L versus 2922 ± 2773 μg/L; p < 0.0001 ).
Conclusions.
In patients with β-T major a progressive damage of insulin-producing cells due to secondary hemosiderosis appears to be the most reasonable mechanism associated with glucose metabolism disorders.
The findings need to be confirmed with additional well designed studies to address the question of whether TPOAb may have a role in the management of these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pes, Gianni& Tolu, Francesco& Dore, Maria Pina. 2016. Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107960
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pes, Gianni…[et al.]. Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major. Journal of Diabetes Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1107960
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pes, Gianni& Tolu, Francesco& Dore, Maria Pina. Anti-Thyroid Peroxidase Antibodies and Male Gender Are Associated with Diabetes Occurrence in Patients with Beta-Thalassemia Major. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107960
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107960
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر