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Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases
المؤلفون المشاركون
Zhang, Chi
Lu, Xuemian
Cheng, Peng
Zhang, Fangfang
Yu, Lechu
Lin, Xiufei
He, Luqing
Li, Xiaokun
Yan, Xiaoqing
Tan, Yi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cardiovascular disease (CVD) is one of the most severe diseases in clinics.
Fibroblast growth factor 21 (FGF21) is regarded as an important metabolic regulator playing a therapeutic role in diabetes and its complications.
The heart is a key target as well as a source of FGF21 which is involved in heart development and also induces beneficial effects in CVDs.
Our review is to clarify the roles of FGF21 in CVDs.
Strong evidence showed that the development of CVDs including atherosclerosis, coronary heart disease, myocardial ischemia, cardiac hypertrophy, and diabetic cardiomyopathy is associated with serum FGF21 levels increase which was regarded as a compensatory response to induced cardiac protection.
Furthermore, administration of FGF21 suppressed the above CVDs.
Mechanistic studies revealed that FGF21 induced cardiac protection likely by preventing cardiac lipotoxicity and the associated oxidative stress, inflammation, and apoptosis.
Normally, FGF21 induced therapeutic effects against CVDs via activation of the above kinases-mediated pathways by directly binding to the FGF receptors of the heart in the presence of β-klotho.
However, recently, growing evidence showed that FGF21 induced beneficial effects on peripheral organs through an indirect way mediated by adiponectin.
Therefore whether adiponectin is also involved in FGF21-induced cardiac protection still needs further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cheng, Peng& Zhang, Fangfang& Yu, Lechu& Lin, Xiufei& He, Luqing& Li, Xiaokun…[et al.]. 2016. Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107966
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cheng, Peng…[et al.]. Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1107966
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cheng, Peng& Zhang, Fangfang& Yu, Lechu& Lin, Xiufei& He, Luqing& Li, Xiaokun…[et al.]. Physiological and Pharmacological Roles of FGF21 in Cardiovascular Diseases. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1107966
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107966
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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