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Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets
المؤلفون المشاركون
Gao, Jie
Ansarullah, Kayo
Free, Colette
Christopherson, Jenica
Chen, Quanhai
Liu, Chengyang
Naji, Ali
Rabinovitch, Alex
Guo, Zhiguang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-16
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Using humanized mice with functional human islets, we investigated whether activating GPR119 by PSN632408, a small molecular agonist, can stimulate human β-cell regeneration in vivo.
Human islets were transplanted under the left kidney capsule of immunodeficient mice with streptozotocin- (STZ-) induced diabetes.
The recipient mice were treated with PSN632408 or vehicle and BrdU daily.
Human islet graft function in the mice was evaluated by nonfasting glucose levels, oral glucose tolerance, and removal of the grafts.
Immunostaining for insulin, glucagon, and BrdU or Ki67 was performed in islet grafts to evaluate α- and β-cell replication.
Insulin and CK19 immunostaining was performed to evaluate β-cell neogenesis.
Four weeks after human islet transplantation, 71% of PSN632408-treated mice achieved normoglycaemia compared with 24% of vehicle-treated mice.
Also, oral glucose tolerance was significantly improved in the PSN632408-treated mice.
PSN632408 treatment significantly increased both human α- and β-cell areas in islet grafts and stimulated α- and β-cell replication.
In addition, β-cell neogenesis was induced from pancreatic duct cells in the islet grafts.
Our results demonstrated that activation of GPR119 increases β-cell mass by stimulating human β-cell replication and neogenesis.
Therefore, GPR119 activators may qualify as therapeutic agents to increase human β-cell mass in patients with diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ansarullah, Kayo& Free, Colette& Christopherson, Jenica& Chen, Quanhai& Gao, Jie& Liu, Chengyang…[et al.]. 2016. Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1107974
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ansarullah, Kayo…[et al.]. Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1107974
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ansarullah, Kayo& Free, Colette& Christopherson, Jenica& Chen, Quanhai& Gao, Jie& Liu, Chengyang…[et al.]. Activation of GPR119 Stimulates Human β-Cell Replication and Neogenesis in Humanized Mice with Functional Human Islets. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1107974
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107974
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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