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Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats
المؤلفون المشاركون
Okpashi, Victor Eshu
Chukwunonso Obi, Bonaventure
Chinwuba Okoye, Theophine
Nonye Igwe, Christiana
Olisah Alumanah, Edwin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Diabetes mellitus is one of the serious global health problems affecting a significant proportion of both developed and developing countries.
Overproduction of free radicals and oxidative stress has been associated with the development of diabetic complications.
In the present study, the antioxidant effects of metformin (MET), glibenclamide (GLI), and repaglinide (REP) were evaluated in alloxan-induced diabetic rats.
The findings from this study may possibly help in understanding the efficacy of these standard drugs in managing the complications arising from diabetes mellitus (DM).
Alloxan (130 mg/kg BW) was administered as a single dose to induce diabetes.
Four (4) groups of rats ( n = 6 ) were used; group 1 served as diabetic control while groups 2, 3, and 4 were the diabetic test groups that received MET (25 mg/kg), GLI (2.5 mg/kg), and REP (0.5 mg/kg), respectively.
The result of the study showed significant ( p < 0.05 ) improvement in the altered antioxidant enzymes (SOD, CAT) and GSH concentration in diabetic treated rats compared with the diabetic control group.
MET and REP produced significant effect on the MDA concentration while GLI showed insignificant reduction in the MDA concentration compared with the diabetic control.
Findings from this study suggest that the administration of MET, GLI, and REP exerts significant antioxidant effects in alloxan-induced diabetic rats, thus contributing to the protective effect against oxidative stress-induced damage during diabetic complications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chukwunonso Obi, Bonaventure& Chinwuba Okoye, Theophine& Okpashi, Victor Eshu& Nonye Igwe, Christiana& Olisah Alumanah, Edwin. 2015. Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chukwunonso Obi, Bonaventure…[et al.]. Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1107976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chukwunonso Obi, Bonaventure& Chinwuba Okoye, Theophine& Okpashi, Victor Eshu& Nonye Igwe, Christiana& Olisah Alumanah, Edwin. Comparative Study of the Antioxidant Effects of Metformin, Glibenclamide, and Repaglinide in Alloxan-Induced Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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