Influence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid Polypeptide
المؤلفون المشاركون
Zhou, Ping
Xu, Zhi-Xue
Zhang, Qiang
Ma, Gong-Li
Chen, Cong-Heng
He, Yan-Ming
Xu, Li-Hui
Zhang, Yuan
Zhou, Guang-Rong
Li, Zhen-Hua
Yang, Hong-Jie
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-15
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The abnormal fibrillation of human islet amyloid polypeptide (hIAPP) has been implicated in the development of type II diabetes.
Aluminum is known to trigger the structural transformation of many amyloid proteins and induce the formation of toxic aggregate species.
The (−)-epigallocatechin gallate (EGCG) is considered capable of binding both metal ions and amyloid proteins with inhibitory effect on the fibrillation of amyloid proteins.
However, the effect of Al(III)/EGCG complex on hIAPP fibrillation is unclear.
In the present work, we sought to view insight into the structures and properties of Al(III) and EGCG complex by using spectroscopic experiments and quantum chemical calculations and also investigated the influence of Al(III) and EGCG on hIAPP fibrillation and aggregation as well as their combined interference on this process.
Our studies demonstrated that Al(III) could promote fibrillation and aggregation of hIAPP, while EGCG could inhibit the fibrillation of hIAPP and lead to the formation of hIAPP amorphous aggregates instead of the ordered fibrils.
Furthermore, we proved that the Al(III)/EGCG complex in molar ratio of 1 : 1 as Al(EGCG)(H2O)2 could inhibit the hIAPP fibrillation more effectively than EGCG alone.
The results provide the invaluable reference for the new drug development to treat type II diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Zhi-Xue& Zhang, Qiang& Ma, Gong-Li& Chen, Cong-Heng& He, Yan-Ming& Xu, Li-Hui…[et al.]. 2016. Influence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid Polypeptide. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Zhi-Xue…[et al.]. Influence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid Polypeptide. Journal of Diabetes Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1107989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Zhi-Xue& Zhang, Qiang& Ma, Gong-Li& Chen, Cong-Heng& He, Yan-Ming& Xu, Li-Hui…[et al.]. Influence of Aluminium and EGCG on Fibrillation and Aggregation of Human Islet Amyloid Polypeptide. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1107989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1107989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر