Association between Self-Reported Habitual Snoring and Diabetes Mellitus: A Systemic Review and Meta-Analysis

الملخص EN

Aim.

Several studies have reported an association between self-reported habitual snoring and diabetes mellitus (DM); however, the results are inconsistent.

Methods.

Electronic databases including PubMed and EMBASE were searched.

Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association between snoring and DM using a random-effects model.

Heterogeneity, subgroup, and sensitivity analyses were also evaluated.

Begg’s, Egger’s tests and funnel plots were used to evaluate publication bias.

Results.

A total of eight studies (six cross sectional and two prospective cohort studies) pooling 101,246 participants were included.

Of the six cross sectional studies, the summary OR and 95% CI of DM in individuals that snore compared with nonsnorers were 1.37 (95% CI: 1.20–1.57, p < 0.001 ).

There was no heterogeneity across the included studies ( I 2 = 2.9 %, p = 0.408 ).

When stratified by gender, the pooled OR (95% CI) was 1.59 (1.20–2.11) in females ( n = 12298 ), and 0.89 (0.65–1.22) in males ( n = 4276 ).

Of the two prospective studies, the pooled RR was 1.65 (95% CI, 1.30–2.08).

Conclusions.

Self-reported habitual snoring is statistically associated with DM in females, but not in males.

This meta-analysis indicates a need to paying attention to the effect of snoring on the occurrence of DM in females.