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An Investigation into the Antiobesity Effects of Morinda citrifolia L. Leaf Extract in High Fat Diet Induced Obese Rats Using a 1H NMR Metabolomics Approach
المؤلفون المشاركون
Mahmudi, M. Fawzi
Saari, Nazamid
Hamid, Azizah Abdul
Khatib, Alfi
Gooda Sahib, Najla
Ismail, Amin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-20
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The prevalence of obesity is increasing worldwide, with high fat diet (HFD) as one of the main contributing factors.
Obesity increases the predisposition to other diseases such as diabetes through various metabolic pathways.
Limited availability of antiobesity drugs and the popularity of complementary medicine have encouraged research in finding phytochemical strategies to this multifaceted disease.
HFD induced obese Sprague-Dawley rats were treated with an extract of Morinda citrifolia L.
leaves (MLE 60).
After 9 weeks of treatment, positive effects were observed on adiposity, fecal fat content, plasma lipids, and insulin and leptin levels.
The inducement of obesity and treatment with MLE 60 on metabolic alterations were then further elucidated using a 1H NMR based metabolomics approach.
Discriminating metabolites involved were products of various metabolic pathways, including glucose metabolism and TCA cycle (lactate, 2-oxoglutarate, citrate, succinate, pyruvate, and acetate), amino acid metabolism (alanine, 2-hydroxybutyrate), choline metabolism (betaine), creatinine metabolism (creatinine), and gut microbiome metabolism (hippurate, phenylacetylglycine, dimethylamine, and trigonelline).
Treatment with MLE 60 resulted in significant improvement in the metabolic perturbations caused obesity as demonstrated by the proximity of the treated group to the normal group in the OPLS-DA score plot and the change in trajectory movement of the diseased group towards the healthy group upon treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gooda Sahib, Najla& Saari, Nazamid& Ismail, Amin& Khatib, Alfi& Mahmudi, M. Fawzi& Hamid, Azizah Abdul. 2015. An Investigation into the Antiobesity Effects of Morinda citrifolia L. Leaf Extract in High Fat Diet Induced Obese Rats Using a 1H NMR Metabolomics Approach. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108013
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gooda Sahib, Najla…[et al.]. An Investigation into the Antiobesity Effects of Morinda citrifolia L. Leaf Extract in High Fat Diet Induced Obese Rats Using a 1H NMR Metabolomics Approach. Journal of Diabetes Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1108013
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gooda Sahib, Najla& Saari, Nazamid& Ismail, Amin& Khatib, Alfi& Mahmudi, M. Fawzi& Hamid, Azizah Abdul. An Investigation into the Antiobesity Effects of Morinda citrifolia L. Leaf Extract in High Fat Diet Induced Obese Rats Using a 1H NMR Metabolomics Approach. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1108013
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108013
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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