Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer
المؤلفون المشاركون
Wei, Wenhui
Mattes, Malcolm D.
Sambamoorthi, Usha
Raval, Amit D.
Pan, Xiaoyun
Madhavan, Suresh
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To examine the association between metformin use and cancer stage at diagnosis among elderly men with preexisting diabetes mellitus and incident prostate cancer.
Methods.
This study used a population-based observational cohort of elderly men (≥66 years) with preexisting diabetes and incident prostate cancer between 2008 and 2009 ( N = 2,652 ).
Cancer stage at diagnosis (localized versus advanced) was based on the American Joint Cancer Committee classification.
Metformin use and other independent variables were measured during the one year before cancer diagnosis.
Logistic regressions with inverse probability treatment weights were used to control for the observed selection bias.
Results.
A significantly lower percentage of metformin users were diagnosed with advanced prostate cancer as compared to nonusers (4.7% versus 6.7%, p < 0.03 ).
After adjusting for the observed selection bias and other independent variables, metformin use was associated with a 32% reduction in the risk of advanced prostate cancer (adjusted odds ratio, AOR: 0.68, 95% confidence interval, CI: 0.48, 0.97).
Conclusions.
This is the first epidemiological study to support the role of metformin in reducing the risk of advanced prostate cancer.
Randomized clinical trials are needed to confirm the causal link between metformin use and prostate cancer diagnosis stage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Raval, Amit D.& Mattes, Malcolm D.& Madhavan, Suresh& Pan, Xiaoyun& Wei, Wenhui& Sambamoorthi, Usha. 2016. Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108026
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Raval, Amit D.…[et al.]. Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer. Journal of Diabetes Research No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1108026
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Raval, Amit D.& Mattes, Malcolm D.& Madhavan, Suresh& Pan, Xiaoyun& Wei, Wenhui& Sambamoorthi, Usha. Association between Metformin Use and Cancer Stage at Diagnosis among Elderly Medicare Beneficiaries with Preexisting Type 2 Diabetes Mellitus and Incident Prostate Cancer. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1108026
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108026
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر