A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice
المؤلفون المشاركون
Nawroth, Peter Paul
Wortmann, Markus
Hakimi, Maani
Peters, Andreas S.
Sijmonsma, Tjeerd P.
Herzig, Stephan
Böckler, Dittmar
Dihlmann, Susanne
Fleming, Thomas H.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-15
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
Glyoxalase-1 is an enzyme detoxifying methylglyoxal (MG).
MG is a potent precursor of advanced glycation endproducts which are regarded to be a key player in micro- and macrovascular damage.
Yet, the role of Glo1 in atherosclerosis remains unclear.
In this study, the effect of Glo1 on mouse metabolism and atherosclerosis is evaluated.
Methods.
Glo1 knockdown mice were fed a high fat or a standard diet for 10 weeks.
Body weight and composition were investigated by Echo MRI.
The PhenoMaster system was used to measure the energy expenditure.
To evaluate the impact of Glo1 on atherosclerosis, Glo1KD mice were crossed with ApoE-knockout mice and fed a high fat diet for 14 weeks.
Results.
Glo1 activity was significantly reduced in heart, liver, and kidney lysates derived from Glo1KD mice.
Yet, there was no increase in methylglyoxal-derived AGEs in all organs analyzed.
The Glo1 knockdown did not affect body weight or body composition.
Metabolic studies via indirect calorimetry did not show significant effects on energy expenditure.
Glo1KD mice crossed to ApoE−/− mice did not show enhanced formation of atherosclerosis.
Conclusion.
A Glo1 knockdown does not have major short term effects on the energy expenditure or the formation of atherosclerotic plaques.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wortmann, Markus& Hakimi, Maani& Fleming, Thomas H.& Peters, Andreas S.& Sijmonsma, Tjeerd P.& Herzig, Stephan…[et al.]. 2015. A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108045
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wortmann, Markus…[et al.]. A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1108045
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wortmann, Markus& Hakimi, Maani& Fleming, Thomas H.& Peters, Andreas S.& Sijmonsma, Tjeerd P.& Herzig, Stephan…[et al.]. A Glyoxalase-1 Knockdown Does Not Have Major Short Term Effects on Energy Expenditure and Atherosclerosis in Mice. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1108045
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108045
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر