Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function
المؤلفون المشاركون
Cardona-Muñoz, Ernesto German
Rodríguez-Carrizalez, Adolfo Daniel
Villegas-Rivera, Geannyne
Miranda-Díaz, Alejandra Guillermina
Román-Pintos, L. M.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-12
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Diabetic polyneuropathy (DPN) is defined as peripheral nerve dysfunction.
There are three main alterations involved in the pathologic changes of DPN: inflammation, oxidative stress, and mitochondrial dysfunction.
Inflammation induces activation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinases.
Oxidative stress induced by hyperglycemia is mediated by several identified pathways: polyol, hexosamine, protein kinase C, advanced glycosylation end-products, and glycolysis.
In addition, mitochondrial dysfunction accounts for most of the production of reactive oxygen and nitrosative species.
These free radicals cause lipid peroxidation, protein modification, and nucleic acid damage, to finally induce axonal degeneration and segmental demyelination.
The prevalence of DPN ranges from 2.4% to 78.8% worldwide, depending on the diagnostic method and the population assessed (hospital-based or outpatients).
Risk factors include age, male gender, duration of diabetes, uncontrolled glycaemia, height, overweight and obesity, and insulin treatment.
Several diagnostic methods have been developed, and composite scores combined with nerve conduction studies are the most reliable to identify early DPN.
Treatment should be directed to improve etiologic factors besides reducing symptoms; several approaches have been evaluated to reduce neuropathic impairments and improve nerve conduction, such as oral antidiabetics, statins, and antioxidants (alpha-lipoic acid, ubiquinone, and flavonoids).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Román-Pintos, L. M.& Villegas-Rivera, Geannyne& Rodríguez-Carrizalez, Adolfo Daniel& Miranda-Díaz, Alejandra Guillermina& Cardona-Muñoz, Ernesto German. 2016. Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108060
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Román-Pintos, L. M.…[et al.]. Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function. Journal of Diabetes Research No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1108060
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Román-Pintos, L. M.& Villegas-Rivera, Geannyne& Rodríguez-Carrizalez, Adolfo Daniel& Miranda-Díaz, Alejandra Guillermina& Cardona-Muñoz, Ernesto German. Diabetic Polyneuropathy in Type 2 Diabetes Mellitus: Inflammation, Oxidative Stress, and Mitochondrial Function. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1108060
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108060
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر