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Impact of Pancreatic Rat Islet Density on Cell Survival during Hypoxia
المؤلفون المشاركون
Bietiger, William
Pinget, Michel
Jeandidier, Nathalie
Maillard, Elisa
Sigrist, Séverine
Rodriguez-Brotons, A.
Peronet, C.
Magisson, J.
Sookhareea, C.
Langlois, A.
Mura, C.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
In bioartificial pancreases (BP), the number of islets needed to restore normoglycaemia in the diabetic patient is critical.
However, the confinement of a high quantity of islets in a limited space may impact islet survival, particularly in regard to the low oxygen partial pressure (PO2) in such environments.
The aim of the present study was to evaluate the impact of islet number in a confined space under hypoxia on cell survival.
Rat islets were seeded at three different concentrations (150, 300, and 600 Islet Equivalents (IEQ)/cm2) and cultured in normal atmospheric pressure (160 mmHg) as well as hypoxic conditions (15 mmHg) for 24 hours.
Cell viability, function, hypoxia-induced changes in gene expression, and cytokine secretion were then assessed.
Notably, hypoxia appeared to induce a decrease in viability and increasing islet density exacerbated the observed increase in cellular apoptosis as well as the loss of function.
These changes were also associated with an increase in inflammatory gene transcription.
Taken together, these data indicate that when a high number of islets are confined to a small space under hypoxia, cell viability and function are significantly impacted.
Thus, in order to improve islet survival in this environment during transplantation, oxygenation is of critical importance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rodriguez-Brotons, A.& Bietiger, William& Peronet, C.& Magisson, J.& Sookhareea, C.& Langlois, A.…[et al.]. 2015. Impact of Pancreatic Rat Islet Density on Cell Survival during Hypoxia. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108070
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rodriguez-Brotons, A.…[et al.]. Impact of Pancreatic Rat Islet Density on Cell Survival during Hypoxia. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108070
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rodriguez-Brotons, A.& Bietiger, William& Peronet, C.& Magisson, J.& Sookhareea, C.& Langlois, A.…[et al.]. Impact of Pancreatic Rat Islet Density on Cell Survival during Hypoxia. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108070
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108070
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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