Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus
المؤلفون المشاركون
Klupa, Tomasz
Matejko, Bartlomiej
Mrozinska, Sandra
Szopa, Magdalena
Malecki, Maciej T.
Gosiewski, Tomasz
Bulanda, Małgorzata
Radkowski, Piotr
Ludwig-Galezowska, Agnieszka H.
Morawska, Iwona
Sroka-Oleksiak, Agnieszka
Kapusta, Przemyslaw
Salamon, Dominika
Wolkow, Pawel
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Type 2 diabetes mellitus (T2DM) is determined by genetic and environmental factors.
There have been many studies on the relationship between the composition of the gastrointestinal bacterial flora, T2DM, and obesity.
There are no data, however, on the gut microbiome structure in monogenic forms of the disease including Maturity Onset Diabetes of the Young (MODY).
Methods.
The aim of the investigation was to compare the qualitative parameters of the colonic flora in patients with HNF1A-MODY and T2DM and healthy individuals.
16S sequencing of bacterial DNA isolated from the collected fecal samples using the MiSeq platform was performed.
Results.
There were significant between-group differences in the bacterial profile.
At the phylum level, the amount of Proteobacteria was higher (p=0.0006) and the amount of Bacteroidetes was lower (p=0.0005) in T2DM group in comparison to the control group.
In HNF1A-MODY group, the frequency of Bacteroidetes was lower than in the control group (p=0.0143).
At the order level, Turicibacterales was more abundant in HNF1A-MODY group than in T2DM group.
Conclusions.
It appears that there are differences in the gut microbiome composition between patients with HNF1A-MODY and type 2 diabetes.
Further investigation on this matter should be conducted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mrozinska, Sandra& Radkowski, Piotr& Gosiewski, Tomasz& Szopa, Magdalena& Bulanda, Małgorzata& Ludwig-Galezowska, Agnieszka H.…[et al.]. 2016. Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mrozinska, Sandra…[et al.]. Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mrozinska, Sandra& Radkowski, Piotr& Gosiewski, Tomasz& Szopa, Magdalena& Bulanda, Małgorzata& Ludwig-Galezowska, Agnieszka H.…[et al.]. Qualitative Parameters of the Colonic Flora in Patients with HNF1A-MODY Are Different from Those Observed in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر