Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice
المؤلفون المشاركون
Xie, Yong
Zhang, Yi
Guo, Zebin
Zeng, Hongliang
Zheng, Baodong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study aimed to investigate the effects of total alkaloids from Nelumbinis Plumula (NPA) on insulin resistance (IR) of high-fat diet- (HFD-) induced nonalcoholic fatty liver disease (NAFLD).
Rats were fed with HFD for 8 weeks to induce NAFLD.
Then, the effect of NPA on ameliorating IR in HFD-induced NAFLD was evaluated.
Fasting serum insulin was determined using an enzyme-linked immunosorbent assay (ELISA) kit for insulin following the manufacturer’s protocol.
Some inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) were determined using ELISA kits to assess the inflammatory burden in rats.
The results showed that HFD could induce a significant increase in blood glucose and IR in rats.
However, rats treated with NPA (400 or 600 mg/kg) showed improved IR and reduction in serum inflammatory cytokines TNF-α and IL-6.
Further investigation indicated that NPA could inhibit IR by restoring the insulin receptor substrate-1 (IRS-1) and suppressing the expression of c-Jun N-terminal kinase (JNK) phosphorylation.
The present results supported the view that the pathogenesis of NAFLD was complex with inflammation, together with increasing serum glucose and IR.
Also, JNK and IRS phosphorylation were suggested for their involvement in the modulating of IR during NAFLD progression.
Therefore, NPA may serve as a potential natural remedy against IR in NAFLD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Yong& Zhang, Yi& Guo, Zebin& Zeng, Hongliang& Zheng, Baodong. 2016. Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Yong…[et al.]. Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Yong& Zhang, Yi& Guo, Zebin& Zeng, Hongliang& Zheng, Baodong. Effect of Alkaloids from Nelumbinis Plumula against Insulin Resistance of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر