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Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3KAkt Signalling Pathway
المؤلفون المشاركون
Yu, Wei
Zha, Wenliang
Ke, Zhiqiang
Min, Qing
Li, Cairong
Sun, Huirong
Liu, Chao
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The function of curcumin on NADPH oxidase-related ROS production and cardiac apoptosis, together with the modulation of protein signalling pathways, was investigated in cardiomyocytes.
Primary cultures of neonatal rat cardiomyocytes were exposed to 30 mmol/L high glucose with or without curcumin.
Cell viability, apoptosis, superoxide formation, the expression of NADPH oxidase subunits, and potential regulatory molecules, Akt and GSK-3β, were assessed in cardiomyocytes.
Cardiomyocytes exposure to high glucose led to an increase in both cell apoptosis and intracellular ROS levels, which were strongly prevented by curcumin treatment (10 μM).
In addition, treatment with curcumin remarkably suppressed the increased activity of Rac1, as well as the enhanced expression of g p 91 p h o x and p 47 p h o x induced by high glucose.
Lipid peroxidation and SOD were reversed in the presence of curcumin.
Furthermore, curcumin treatment markedly inhibited the reduced Bcl-2/Bax ratio elicited by high glucose exposure.
Moreover, curcumin significantly increased Akt and GSK-3β phosphorylation in cardiomyocytes treated with high glucose.
In addition, LY294002 blocked the effects of curcumin on cardiomyocytes exposure to high glucose.
In conclusion, these results demonstrated that curcumin attenuated high glucose-induced cardiomyocyte apoptosis by inhibiting NADPH-mediated oxidative stress and this protective effect is most likely mediated by PI3K/Akt-related signalling pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Wei& Zha, Wenliang& Ke, Zhiqiang& Min, Qing& Li, Cairong& Sun, Huirong…[et al.]. 2016. Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3KAkt Signalling Pathway. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108100
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Wei…[et al.]. Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3KAkt Signalling Pathway. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108100
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Wei& Zha, Wenliang& Ke, Zhiqiang& Min, Qing& Li, Cairong& Sun, Huirong…[et al.]. Curcumin Protects Neonatal Rat Cardiomyocytes against High Glucose-Induced Apoptosis via PI3KAkt Signalling Pathway. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108100
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108100
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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