Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis
المؤلفون المشاركون
Lei, Xiaotian
QiNan, Wu
XiaGuang, Gan
WuQuan, Deng
ZiWen, Liang
Chen, Bing
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To investigate the effect and mechanism of the exenatide on diabetic cardiomyopathy.
Methods.
Rats were divided into control group, diabetes group (D), diabetes treated with insulin (DI) group, and diabetes treat with exenatide (DE) group.
We detected apoptosis rate by TUNEL, the adiponectin and high molecular weight adiponectin (HMW-adiponectin) by ELISA, and the expression of APPL1, p-AMPK/T-AMPK, PPARα, and NF-κB by immunohistochemistry and western blotting.
Results.
Compared with the D group, the apoptosis in the Control and DE groups was decreased ( P < 0.05 ); the adiponectin and HMW-adiponectin were increased ( P < 0.05 ); the APPL1, p-AMPK/T-AMPK, PPARα, and LV −dP/dt were increased ( P < 0.05 ); and the NF-κB, GRP78, and LVEDP were decreased ( P < 0.05 ).
Compared with DE group, the glucose levels in the DI group were similar ( P < 0.05 ); the apoptosis and LVEDP were increased; the APPL1, p-AMPK/T-AMPK, PPARα, and LV −dP/dt were decreased ( P < 0.05 ); the NF-κB and GRP78 were increased ( P < 0.05 ); the adiponectin and HMW-adiponectin were significantly decreased ( P < 0.05 ).
Conclusion.
Our model of diabetic cardiomyopathy was constructed successfully.
After being treated with exenatide, the adiponectin and HMW-adiponectin and the APPL1-AMPK-PPARα axis were increased, the NF-κB and the apoptosis were decreased, the cardiac function of the diabetic rats was improved, and these effects were independent of glucose control.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lei, Xiaotian& QiNan, Wu& XiaGuang, Gan& WuQuan, Deng& Chen, Bing& ZiWen, Liang. 2015. Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lei, Xiaotian…[et al.]. Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lei, Xiaotian& QiNan, Wu& XiaGuang, Gan& WuQuan, Deng& Chen, Bing& ZiWen, Liang. Exenatide Activates the APPL1-AMPK-PPARα Axis to Prevent Diabetic Cardiomyocyte Apoptosis. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر