Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis

المؤلفون المشاركون

Sun, Xin
Tian, Hao-Ming
Li, Qianrui
Li, Sheyu
Liu, Dan
Li, Ling
Li, Yun
An, Zhenmei

المصدر

Journal of Diabetes Research

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-12-01

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Objective.

To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human.

Methods.

A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing the circulating levels of betatrophin in both T2DM patients and nondiabetic adults.

Results.

A total of nine eligible studies with twelve comparisons were included for the final meta-analysis.

Circulating betatrophin levels in T2DM patients were higher than those in the nondiabetic controls (random-effect SMD 0.53; 95% CI 0.13 to 0.94; P = 0.010 ).

In the subgroup of nonobese population but not the obese population, the overall betatrophin level in T2DM patients was much higher than that in the nondiabetic controls (nonobese: random-effect SMD, 0.82; 95% CI 0.42 to 1.21; P < 0.001 ; obese: random-effect SMD, −0.39; 95% CI, −0.95 to 0.18; P = 0.18 ).

Metaregression indicated that body mass index of T2DM patients was associated with mean difference of betatrophin level between T2DM and nondiabetic adults (slope, −578.8; t = - 2.7 ; P = 0.02 ).

Conclusion.

Based on the findings of our meta-analysis, circulating betatrophin level of T2DM patients is higher than that of nondiabetic adults in the nonobese population, but not in the obese population.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Li, Sheyu& Liu, Dan& Li, Ling& Li, Yun& Li, Qianrui& An, Zhenmei…[et al.]. 2015. Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108191

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Li, Sheyu…[et al.]. Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis. Journal of Diabetes Research No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1108191

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Li, Sheyu& Liu, Dan& Li, Ling& Li, Yun& Li, Qianrui& An, Zhenmei…[et al.]. Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1108191

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1108191