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New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes
المؤلفون المشاركون
Fu, Li
Wang, Zhuguang
Batista, Victor S.
Yan, Elsa C. Y.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Studies of amyloid polypeptides on membrane surfaces have gained increasing attention in recent years.
Several studies have revealed that membranes can catalyze protein aggregation and that the early products of amyloid aggregation can disrupt membrane integrity, increasing water permeability and inducing ion cytotoxicity.
Nonetheless, probing aggregation of amyloid proteins on membrane surfaces is challenging.
Surface-specific methods are required to discriminate contributions of aggregates at the membrane interface from those in the bulk phase and to characterize protein secondary structures in situ and in real time without the use of perturbing spectroscopic labels.
Here, we review the most recent applications of sum frequency generation (SFG) vibrational spectroscopy applied in conjunction with computational modeling techniques, a joint experimental and computational methodology that has provided valuable insights into the aggregation of islet amyloid polypeptide (IAPP) on membrane surfaces.
These applications show that SFG can provide detailed information about structures, kinetics, and orientation of IAPP during interfacial aggregation, relevant to the molecular mechanisms of type II diabetes.
These recent advances demonstrate the promise of SFG as a new approach for studying amyloid diseases at the molecular level and for the rational drug design targeting early aggregation products on membrane surfaces.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fu, Li& Wang, Zhuguang& Batista, Victor S.& Yan, Elsa C. Y.. 2015. New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108234
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fu, Li…[et al.]. New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes. Journal of Diabetes Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1108234
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fu, Li& Wang, Zhuguang& Batista, Victor S.& Yan, Elsa C. Y.. New Insights from Sum Frequency Generation Vibrational Spectroscopy into the Interactions of Islet Amyloid Polypeptides with Lipid Membranes. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108234
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108234
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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