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Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia
المؤلفون المشاركون
Eshkoor, Sima Ataollahi
Heidari, Farzad
Ghodsian, Nooshin
Ismail, Patimah
Haghvirdizadeh, Polin
Etemad, Ali
Ahmadloo, Salma
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-29
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
With-no-lysine (K) Kinase-4 (WNK4) consisted of unique serine and threonine protein kinases, genetically associated with an autosomal dominant form of hypertension.
Argumentative consequences have lately arisen on the association of specific single nucleotide polymorphisms of WNK4 gene and essential hypertension (EHT).
The aim of this study was to determine the association of Ala589Ser polymorphism of WNK4 gene with essential hypertensive patients in Malaysia.
WNK4 gene polymorphism was specified utilizing mutagenically separated polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) method in 320 subjects including 163 cases and 157 controls.
Close relation between Ala589Ser polymorphism and elevated systolic and diastolic blood pressure (SBP and DBP) was recognized.
Sociodemographic factors including body mass index (BMI), age, the level of fasting blood sugar (FBS), low density lipoprotein (LDL), and triglyceride (TG) in the cases and healthy subjects exhibited strong differences (p<0.05).
The distribution of allele frequency and genotype of WNK4 gene Ala589Ser polymorphism showed significant differences (p<0.05) between EHT subjects with or without type 2 diabetes mellitus (T2DM) and normotensive subjects, statistically.
The WNK4 gene variation influences significantly blood pressure increase.
Ala589Ser probably has effects on the enzymic activity leading to enhanced predisposition to the disorder.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghodsian, Nooshin& Ismail, Patimah& Ahmadloo, Salma& Heidari, Farzad& Haghvirdizadeh, Polin& Eshkoor, Sima Ataollahi…[et al.]. 2016. Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108270
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghodsian, Nooshin…[et al.]. Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia. Journal of Diabetes Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1108270
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghodsian, Nooshin& Ismail, Patimah& Ahmadloo, Salma& Heidari, Farzad& Haghvirdizadeh, Polin& Eshkoor, Sima Ataollahi…[et al.]. Novel Association of WNK4 Gene, Ala589Ser Polymorphism in Essential Hypertension, and Type 2 Diabetes Mellitus in Malaysia. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1108270
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1108270
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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